Princeton University Library Catalog

Drug safety evaluation : methods and protocols / edited by Jean-Charles Gautier.

Format:
Book
Language:
English
Published/​Created:
New York, NY : Humana Press, c2011.
Description:
xiii, 431 p. : ill. ; 26 cm.
Series:
Bibliographic references:
Includes bibliographical references and index.
Contents:
PART I. GENERAL TOXICOLOGY -- 1. Developing Combination Drugs in Preclinical Studies / Alberto Lodola -- 2. Preclinical Evaluation of Juvenile Toxicity / Jeanne Stadler -- PART II. PATHOLOGY -- 3. Necropsy and Sampling Procedures in Rodents / Mohamed Slaoui -- 4. Histopathology Procedures: From Tissue Sampling to Histopathological Evaluation / Laurence Fiette -- 5. Principles and Methods of Immunohistochemistry / Jose A. Ramos-Vara -- 6. Tissue Microarrays and Digital Image Analysis / William M. Gallagher -- PART III. GENETIC TOXICOLOGY -- 7. Micronucleus Assay and Labeling of Centromeres with FISH Technique / Micheline Kirsch-Volders -- 8. The Use of Bacterial Repair Endonucleases in the Comet Assay / Andrew R. Collins -- PART IV. SAFETY PHARMACOLOGY -- 9. Manual Whole-Cell Patch-Clamping of the HERG Cardiac K+ Channel / David Rampe -- PART V. INVESTIGATIVE TOXICOLOGY -- 10. Generation and Analysis of Transcriptomics Data / Jonathan D. Tugwood -- 11. Protocols of Two-Dimensional Difference Gel Electrophoresis to Investigate Mechanisms of Toxicity / Jean-Charles Gautier -- 12. Protocols and Applications of Cellular Metabolomics in Safety Studies Using Precision-Cut Tissue Slices and Carbon 13 NMR / Guy Martin -- 13. Statistical Analysis of Quantitative RT-PCR Results / Ting Wang -- 14. Evaluation of Mitochondrial Respiration in Cultured Rat Hepatocytes / Gilles Labbe -- PART VI. SCREENING ASSAYS FOR DEVELOPMENTAL TOXICITY -- 15. FETAX Assay for Evaluation of Developmental Toxicity / Olivier Gillardeaux -- 16. Evaluation of Embryotoxicity Using the Zebrafish Model / Robert L. Tanguay -- PART VII. CHEMICAL PROTEIN ADDUCTS -- 17. Protocols of In Vitro Protein Covalent Binding Studies in Liver / Allen N. Jones -- 18. Utilization of MALDI-TOF to Determine Chemical-Protein Adduct Formation In Vitro / Serrine S. Lau -- 19. Utilization of LC-MS/MS Analyses to Identify Site-Specific Chemical Protein Adducts In Vitro / Serrine S. Lau -- 20. One-Dimensional Western Blotting Coupled to LC-MS/MS Analysis to Identify Chemical-Adducted Proteins in Rat Urine / Serrine S. Lau -- 21. Identification of Chemical-Adducted Proteins in Urine by Multi-dimensional Protein Identification Technology (LC/LC-MS/MS) / Serrine S. Lau -- PART VIII. SAFETY BIOMARKERS -- 22. Optimization of SELDI for Biomarker Detection in Plasma / Jean-Charles Gautier -- 23. Differential Proteomics Incorporating iTRAQ Labeling and Multi-dimensional Separations / William M. Gallagher -- 24. NMR and MS Methods for Metabonomics / Alexander Amberg -- 25. Absolute Quantification of Toxicological Biomarkers by Multiple Reaction Monitoring / Stephen R. Pennington.
Subject(s):
ISBN:
  • 9781603271868
  • 1603271864
OCLC:
678514802
Related name:
RCP:
C - S