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Microbiology of wounds / edited by Steven Percival and Keith Cutting.
Format
Book
Language
English
Published/Created
Boca Raton, FL : CRC Press, [2010], ©2010.
Description
xiv, 385 pages : illustrations (some color) ; 25 cm
Availability
Available Online
Taylor & Francis eBooks Complete
SCI-TECHnetBASE
Copies in the Library
Location
Call Number
Status
Location Service
Notes
ReCAP - Remote Storage
RD95 .M53 2010
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Details
Subject(s)
Wounds and injuries
—
Infections
[Browse]
Wounds and injuries
—
Microbiology
[Browse]
Related name
Percival, Steven L.
[Browse]
Cutting, Keith F.
[Browse]
Summary note
"It is not the presence of microorganisms, but their interaction with patients that determines their influence on wound healing. Documenting this critical but often ignored aspect of the treatment process, Microbiology of Wounds discusses the microbiology and biology of human wounds in relation to infection and non-healing." "The practice of wound healing is dynamic, infinitely complex, nonlinear, and prodigiously individualized to the patient. When one considers the myriad host variables that contribute to the disease state, understanding the intricacies of chronic wounds becomes even more difficult. This book presents the necessary scientific and clinical data pertaining to chronic and acute wounds, and discusses inflammation, epithelialization, granulation tissue, and tissue remodeling. It details techniques for treating chronic and acute wounds and covers the mode of action and efficacy of anti-infectives used in treating wounds. Microbiology of Wounds answers the call for a definitive reference on chronic and acute wounds."--BOOK JACKET.
Bibliographic references
Includes bibliographical references and index.
Contents
Chapter 1. An Introduction to the World of Microbiology and Biofilmology / Steven L. Percival and John G. Thomas
Introduction
A Brief History of Microbiology
The Microbial World
Bacteria
Shapes
Size
Structure of Bacteria
Cell Wall
Structure of Cell Wall in Bacteria.
Capsule/Slime Layer
Ribosomes
Nucleoid
Plasmids
Pili and Fimbriae
Flagella
Chemotaxis
Growth of Bacteria
Lag Phase
Exponential Phase
Stationary Phase
Death Phase
Factors That Affect Growth
pH
Temperature
Oxygen
Control of Microorganisms
Terms Used to Describe Microbial Control
Death of Microorganisms following Exposure to Antimicrobial Agents
Mechanism of Action of Antimicrobials
Effectiveness of the Antibiotic or Antimicrobial
Mechanism of Bacterial Resistance
Transmission of Antibiotic Resistance
Epidemiology
Sources of Pathogens
Acquisition of Pathogens
Control of Disease and Infection
Control of Nosocomial Infections
Historical Aspects of Biofilms
Occurrence of Biofilms
Stages in the Formation of Biofilms
Development of the Conditioning Film and Substratum Effects
Events That Bring Microorganisms into Close Proximity with the Surface
Microbial Adhesion
Role of Pili and Funbriae in Adhesion
Growth and Division of the Microorganisms at the Colonized Surface
Microcolony and Bioffim Formation
Extracellular Polymeric Substances
Gene Transfer
Biofilm Structure
Factors That Govern the Development of Biofilms
Quorum Sensing
Detachment and Dispersal of the Biofilm
Public and Medical Health Consequences of Biofilms
Drinking Water
Hospital and Domestic Water
Dental Water Units
Kidney Stones
Endocarditis
Cystic Fibrosis
Otitis Media.
Osteomyelitis
Prostatitis
Intra-amniotic Infection
Indwelling and Medical Devices
Urinary Tract Infections
Central Venous Catheters
Endotracheal Tubes (ETTs)
Rhinosinusitis
Ophthalmic Infections
Oral Infections
Chronic Wounds
Biofilm Resistance
Binding/Failure of the Antimicrobial to Penetrate the Biofilm
Slow Growth and the Stress Response
Heterogeneity
Induction of a Biofilm Phenotype
Conclusion
References
Chapter 2. Human Skin and Microbial Flora / David Williams and Rose A. Cooper
The Anatomy and Characteristics of Human Skin
The Protective and Defensive Mechanisms of Human Skin
The Distribution of Microbial Flora on the Skin
Inhibitory Factors
Other Factors
Investigations into the Normal Flora of the Skin of Healthy Adults
The Distribution of Indigenous Microbiota
Molecular Approaches to the Investigation of Skin Microbiota
Normal Residents of Skin in Health and Infection
Corynebacterium
Micrococcaceae
Staphylococcus epidermidis
Staphylococcus aureus
Propionibacterium spp.
Group A Streptococcus (Streptococcus pyogenes)
Pseudonwnas aeruginosa
Acinetobacter species
Fungal species
Bacterial Interactions on the Skin
Skin Flora and Infection
Skin Microflora and Human Immunity
Chapter 3. An Introduction to Wounds / Steven L. Percival and Michel H.E. Hermans
Classification/Terminology
Differences in Physiology
Influence of Microorganisms
Differences in Treatment
Conversion.
Treatment Objectives and Outcomes
General Guidelines of Surgical Wound Management
Surgical Wounds
Sutured Wounds
Lesions with Pus
Thermal Injuries
Types of Burns
Radiation Necrosis
Depth of Burns
Depth Diagnosis
Physiology of the Burn Wound
Size of the Burn, Inhalation Injury, and Burn Disease
First Aid and Guidelines for Referral
Long-Term Results
Frostbite
Chemical Injuries
Skin Donor Sites
Necrotizing Fasciitis and Bacterial Myonecrosis
Diagnosis
Management
Purpura Fulminans
Toxic Epidermal Necrolysis and Stevens-Johnson Syndrome
Skin Tears
Pretibial Laceration
Zoonoses: Bite and Scratch Wounds
Road Rash, Abrasions, Mechanical Blisters
Chronic Wounds: Their Occurrence and Impact
Venous Ulcer
Diabetic Ulcer
Pressure Ulcers
Stage II Pressure Ulcers
Stage III Pressure Ulcers
Stage IV Pressure Ulcers
Other Pressure Ulcers
Prevention of Pressure Ulcers
Arterial Ulcers
Chapter 4. Burn Wound Management / Terry Treadwell
Principles of Wound Management in Burn Care
Burn Wound Infection
First-Degree Burns
Superficial Partial Thickness Burns
Deep Partial Thickness Burns
Mixed Partial Thickness Burns
Full Thickness Burns
Donor Sites
Chemical Lesions
Chapter 5. Cell Biology of Normal and Impaired Healing / Michel H.E. Hermans
Principal Cells Involved in Healing
Platelets
Neutrophils
Macrophages
Endothelial Cells
Fibroblasts
Keratinocytes
Cell Interactions during Normal Healing
Hemostasis
Inflammation
Resolution of Inflammation
Lymphocytes
Granulation Tissue Formation
Reepithelialization
Remodeling
Cytokines and Growth Factors in Regulation of Healing
Properties of Key Growth Factors and Cytokines
Platelet-Derived Growth Factor
Transforming Growth Factor-β
Fibroblast Growth Factor
Epidermal Growth Factor
Vascular Endothelial Growth Factor
Insulin-Like Growth Factor
Cytokines and Chemokines
Interleukin-1
Tumor Necrosis Factor-α
Chronic and Impaired Wounds
General Factors Impacting on Healing
Aging
Menopausal Effects
Nutrition
Chronic Wound Etiology
Venous Leg Ulcers
Diabetic Ulcers
Cellular Defects within the Chronic Wound
Epithelialization
Modulation of Wound Cell Biology by Clinical Interventions
Chapter 6. The Microbiology of Wounds / Keith Moore and Steven L. Percival
Stages Involved in Microbiology Progression of a Chronic Wound Infection
Contamination Stage
Colonization: Reversible Adhesion
Colonization: Irreversible Adhesion
Critical Colonization
Infection Local and Systemic
Role of Microorganisms in Wound Healing
Numbers
Species Diversity in Acute and Chronic Wounds
Beta-Hemolytic Streptococcus
Pseudomonas aeruginosa
Anaerobic Bacteria.
Community Hypothesis and Wound Infections/Healing
The Role of a Community
Unculturable Bacteria and Wounds
Sampling of a Wound
Superficial Wound Swabs
Aspirate/1Issue
Wound Sampling Overview
Microbiological Specimen Handling for Laboratory Culture-Based Diagnostics
Microbiological Specimen Handling for Laboratory Molecular-Based Diagnostics
Chapter 7. Types of Wounds and Infections / Scot E. Dowd, Randall D. Wolcott, Keith F. Cutting and Scot E. Dowd
Wound Types
Diabetic Foot Ulcers
Wound Characteristics
Infection
Chapter 8. Biofilms and Significance to Wound Healing / Steven L. Percival, Keith F. Cutting, Randall D. Wolcott and Scot E. Dowd
Brief Overview of the Biology of Wound Healing
Development of Wound Biofilm
Extracellular Polymeric Substances (BPS)
Evidence of Biofilms in Chronic Wounds
Characterizing Biofilm Infection
Immune Stimulation and Retardation by the Biofilm
Biofilm Detachment and Dispersal in Wounds: Clinical Significance
Conclusions --
Chapter 9. Wounds, Enzymes, and Proteases / Steven L. Percival and Steven L. Percival
History and Structure of MMPs
Types, Mode of Action, and Sources of MMPs
Collagenases
Gelatinases
Stromelysins
Membrane-Type Metalloproteinases
Regulation of MMPs
Transcriptional Level Regulation
Zymogen Activation
Tissue Inhibitors of Metalloproteinases (TIMPs)
Overall MMPs in Chronic Wounds
Factors That Stimulate MMPs
Bacteria, Biofilms, and MMPs
Aerobic Bacteria.
Anaerobic Bacteria
Management of MMPs
Chapter 10. Wound Healing Immunology and Bioffims / Christine A. Cochrane, Emma J. Woods, Paul Davis and John Barnett
Overview of the Immune System
The Innate Immune System and Wound Healing
Identification of Microbial Intruders
Components of the Innate Immune System
Adaptive Immunity Wound Interactions
Components of the Adaptive Immune System
Coordinated Responses of the Innate and Adaptive Immune Systems
Bacterial Immune Evasion
Focus on S. aureus and P. aeruginosa Immune Evasion.
Biofilm Formation
Chapter 11. Antimicrobial Interventions for Wounds / Steven L. Percival, Steven L. Percival and Rose A. Cooper
Types of Antimicrobial Agents
The Rationale for Using Antimicrobial Interventions in Wounds
Physical/Mechanical Methods for Reduction/Removal of Bioburden and Biofilms
Debridement
Enzymic Debridement
Biological Debridement
Antibiotics
Antiseptics
Iodine
Mode of Action
Effectiveness on Biofilms
Silver
Efficacy on Biofilms
Polyhexamethylene Biguanides (PHMB)
Efficacy against Biofilms
Chlorhexidine
Acetic Acid.
Honey
Hydrogen Peroxide
Lactoferrin
Xylitol
Bacteriophages
Ethylenediamine ibtraacetic Acid (EDTA)
Effectiveness of Biofilms
Quorum-Sensing Inhibitors
Essential Oils
Conclusions
Chapter 12. Wound Dressings and Other Topical Treatment Modalities in Bioburden Control / Benjamin A. Lipsky
Wound Dressings
Generic Dressing Classes
Hydrocolloids
Alginate Dressings
Negative Pressure Wound Therapy
Biosurgery
Hype/bade Oxygen
Sequestration
Control of Bacterial Virulence Determinants
Dressing Leakage and Strike-Through
The Microbiological Barrier Properties of Dressings
The Value of Close Association of Dressing with the Wound Bed
Fluid Handling Properties: Absorption/Retention, Lateral Wicking, Sequestration
Chapter 13. Factors Affecting the Healing of Chronic Wounds: An Iconoclastic View / Richard White and Marissa J. Carter
Pressure Ulcers as an Example of Chronic Wounds
Colonization, Infections, and Wound Healing
The Chronic Wound: What to Do?
Basic Wound Care
Compliance with Basic Wound Care
Basic Wound Care Clinical Practice Guidelines
The Technology Ceiling
A Short History of High-Tech Wound Healing 'Treatments
The Verdict on Advanced Wound-Healing 'Technologies
Efficacy versus Effectiveness
Ischemia and Cellular Hypoxia
Where Do We Go from Here?
Silver-Impregnated Wound Dressings as an Example of Advanced Technology
The Concept
Clinical Use of Silver-Impregnated Dressings
Systematic Review and Meta-Analysis
References.
Show 312 more Contents items
ISBN
9781420079937 (hardcover : alk. paper)
142007993X (hardcover : alk. paper)
LCCN
2010005449
OCLC
495598953
RCP
C - S
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Microbiology of wounds / edited by Steven Percival and Keith Cutting.
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