Princeton University Library Catalog

Microbiology of wounds / edited by Steven Percival and Keith Cutting.

Format:
Book
Language:
English
Published/​Created:
Boca Raton, FL : CRC Press, c2010.
Description:
xiv, 385 p. : ill. (some col.) ; 25 cm.
Summary note:
"It is not the presence of microorganisms, but their interaction with patients that determines their influence on wound healing. Documenting this critical but often ignored aspect of the treatment process, Microbiology of Wounds discusses the microbiology and biology of human wounds in relation to infection and non-healing." "The practice of wound healing is dynamic, infinitely complex, nonlinear, and prodigiously individualized to the patient. When one considers the myriad host variables that contribute to the disease state, understanding the intricacies of chronic wounds becomes even more difficult. This book presents the necessary scientific and clinical data pertaining to chronic and acute wounds, and discusses inflammation, epithelialization, granulation tissue, and tissue remodeling. It details techniques for treating chronic and acute wounds and covers the mode of action and efficacy of anti-infectives used in treating wounds. Microbiology of Wounds answers the call for a definitive reference on chronic and acute wounds."--BOOK JACKET.
Bibliographic references:
Includes bibliographical references and index.
Contents:
  • Chapter 1. An Introduction to the World of Microbiology and Biofilmology / Steven L. Percival and John G. Thomas -- Introduction -- A Brief History of Microbiology -- The Microbial World -- Bacteria -- Shapes -- Size -- Structure of Bacteria -- Cell Wall -- Structure of Cell Wall in Bacteria. -- Capsule/Slime Layer -- Ribosomes -- Nucleoid -- Plasmids -- Pili and Fimbriae -- Flagella -- Chemotaxis -- Growth of Bacteria -- Lag Phase -- Exponential Phase -- Stationary Phase -- Death Phase -- Factors That Affect Growth -- pH -- Temperature -- Oxygen -- Control of Microorganisms -- Terms Used to Describe Microbial Control -- Death of Microorganisms following Exposure to Antimicrobial Agents -- Mechanism of Action of Antimicrobials -- Effectiveness of the Antibiotic or Antimicrobial -- Mechanism of Bacterial Resistance -- Transmission of Antibiotic Resistance -- Epidemiology -- Sources of Pathogens -- Acquisition of Pathogens -- Control of Disease and Infection -- Control of Nosocomial Infections -- Historical Aspects of Biofilms -- Occurrence of Biofilms -- Stages in the Formation of Biofilms -- Development of the Conditioning Film and Substratum Effects -- Events That Bring Microorganisms into Close Proximity with the Surface -- Microbial Adhesion -- Role of Pili and Funbriae in Adhesion -- Growth and Division of the Microorganisms at the Colonized Surface -- Microcolony and Bioffim Formation -- Extracellular Polymeric Substances -- Gene Transfer -- Biofilm Structure -- Factors That Govern the Development of Biofilms -- Quorum Sensing -- Detachment and Dispersal of the Biofilm -- Public and Medical Health Consequences of Biofilms -- Drinking Water -- Hospital and Domestic Water -- Dental Water Units -- Kidney Stones -- Endocarditis -- Cystic Fibrosis -- Otitis Media. -- Osteomyelitis -- Prostatitis -- Intra-amniotic Infection -- Indwelling and Medical Devices -- Urinary Tract Infections -- Central Venous Catheters -- Endotracheal Tubes (ETTs) -- Rhinosinusitis -- Ophthalmic Infections -- Oral Infections -- Chronic Wounds -- Biofilm Resistance -- Binding/Failure of the Antimicrobial to Penetrate the Biofilm -- Slow Growth and the Stress Response -- Heterogeneity -- Induction of a Biofilm Phenotype -- Conclusion -- References -- Chapter 2. Human Skin and Microbial Flora / David Williams and Rose A. Cooper -- Introduction -- The Anatomy and Characteristics of Human Skin -- The Protective and Defensive Mechanisms of Human Skin -- The Distribution of Microbial Flora on the Skin -- Inhibitory Factors -- Other Factors -- Investigations into the Normal Flora of the Skin of Healthy Adults -- The Distribution of Indigenous Microbiota -- Molecular Approaches to the Investigation of Skin Microbiota -- Normal Residents of Skin in Health and Infection -- Corynebacterium -- Micrococcaceae -- Staphylococcus epidermidis -- Staphylococcus aureus -- Propionibacterium spp. -- Group A Streptococcus (Streptococcus pyogenes) -- Pseudonwnas aeruginosa -- Acinetobacter species -- Fungal species -- Bacterial Interactions on the Skin -- Skin Flora and Infection -- Skin Microflora and Human Immunity -- Conclusion -- References -- Chapter 3. An Introduction to Wounds / Steven L. Percival and Michel H.E. Hermans -- Classification/Terminology -- Differences in Physiology -- Influence of Microorganisms -- Differences in Treatment -- Conversion. -- Treatment Objectives and Outcomes -- Conclusion -- General Guidelines of Surgical Wound Management -- Surgical Wounds -- Sutured Wounds -- Lesions with Pus -- Thermal Injuries -- Types of Burns -- Radiation Necrosis -- Depth of Burns -- Depth Diagnosis -- Physiology of the Burn Wound -- Size of the Burn, Inhalation Injury, and Burn Disease -- First Aid and Guidelines for Referral -- Long-Term Results -- Frostbite -- Chemical Injuries -- Conclusion -- Skin Donor Sites -- Necrotizing Fasciitis and Bacterial Myonecrosis -- Diagnosis -- Management -- Purpura Fulminans -- Toxic Epidermal Necrolysis and Stevens-Johnson Syndrome -- Skin Tears -- Pretibial Laceration -- Zoonoses: Bite and Scratch Wounds -- Road Rash, Abrasions, Mechanical Blisters -- Chronic Wounds: Their Occurrence and Impact -- Venous Ulcer -- Diabetic Ulcer -- Pressure Ulcers -- Stage II Pressure Ulcers -- Stage III Pressure Ulcers -- Stage IV Pressure Ulcers -- Other Pressure Ulcers -- Prevention of Pressure Ulcers -- Arterial Ulcers -- References -- Chapter 4. Burn Wound Management / Terry Treadwell -- Principles of Wound Management in Burn Care -- Burn Wound Infection -- First-Degree Burns -- Superficial Partial Thickness Burns -- Deep Partial Thickness Burns -- Mixed Partial Thickness Burns -- Full Thickness Burns -- Donor Sites -- Chemical Lesions -- Long-Term Results -- References -- Chapter 5. Cell Biology of Normal and Impaired Healing / Michel H.E. Hermans -- Introduction -- Principal Cells Involved in Healing -- Platelets -- Neutrophils -- Macrophages -- Endothelial Cells -- Fibroblasts -- Keratinocytes -- Cell Interactions during Normal Healing -- Hemostasis -- Inflammation -- Neutrophils -- Macrophages -- Resolution of Inflammation -- Lymphocytes -- Granulation Tissue Formation -- Reepithelialization -- Remodeling -- Cytokines and Growth Factors in Regulation of Healing -- Properties of Key Growth Factors and Cytokines -- Platelet-Derived Growth Factor -- Transforming Growth Factor-β -- Fibroblast Growth Factor -- Epidermal Growth Factor -- Vascular Endothelial Growth Factor -- Insulin-Like Growth Factor -- Cytokines and Chemokines -- Interleukin-1 -- Tumor Necrosis Factor-α -- Chronic and Impaired Wounds -- General Factors Impacting on Healing -- Aging -- Menopausal Effects -- Nutrition -- Other Factors -- Chronic Wound Etiology -- Venous Leg Ulcers -- Diabetic Ulcers -- Pressure Ulcers -- Cellular Defects within the Chronic Wound -- Inflammation -- Granulation Tissue Formation -- Epithelialization -- Modulation of Wound Cell Biology by Clinical Interventions -- References -- Chapter 6. The Microbiology of Wounds / Keith Moore and Steven L. Percival -- Introduction -- Stages Involved in Microbiology Progression of a Chronic Wound Infection -- Contamination Stage -- Colonization: Reversible Adhesion -- Colonization: Irreversible Adhesion -- Critical Colonization -- Infection Local and Systemic -- Role of Microorganisms in Wound Healing -- Numbers -- Species Diversity in Acute and Chronic Wounds -- Staphylococcus aureus -- Beta-Hemolytic Streptococcus -- Pseudomonas aeruginosa -- Anaerobic Bacteria. -- Community Hypothesis and Wound Infections/Healing -- The Role of a Community -- Unculturable Bacteria and Wounds -- Sampling of a Wound -- Superficial Wound Swabs -- Aspirate/1Issue -- Wound Sampling Overview -- Microbiological Specimen Handling for Laboratory Culture-Based Diagnostics -- Microbiological Specimen Handling for Laboratory Molecular-Based Diagnostics -- Conclusion -- References -- Chapter 7. Types of Wounds and Infections / Scot E. Dowd, Randall D. Wolcott, Keith F. Cutting and Scot E. Dowd -- Introduction -- Wound Types -- Diabetic Foot Ulcers -- Venous Leg Ulcers -- Pressure Ulcers -- Wound Characteristics -- Infection -- References -- Chapter 8. Biofilms and Significance to Wound Healing / Steven L. Percival, Keith F. Cutting, Randall D. Wolcott and Scot E. Dowd -- Introduction -- Brief Overview of the Biology of Wound Healing -- Development of Wound Biofilm -- Extracellular Polymeric Substances (BPS) -- Evidence of Biofilms in Chronic Wounds -- Characterizing Biofilm Infection -- Immune Stimulation and Retardation by the Biofilm -- Biofilm Detachment and Dispersal in Wounds: Clinical Significance -- Conclusions --
  • References -- Chapter 9. Wounds, Enzymes, and Proteases / Steven L. Percival and Steven L. Percival -- Introduction -- History and Structure of MMPs -- Types, Mode of Action, and Sources of MMPs -- Collagenases -- Gelatinases -- Stromelysins -- Membrane-Type Metalloproteinases -- Regulation of MMPs -- Transcriptional Level Regulation -- Zymogen Activation -- Tissue Inhibitors of Metalloproteinases (TIMPs) -- Overall MMPs in Chronic Wounds -- Factors That Stimulate MMPs -- Bacteria, Biofilms, and MMPs -- Aerobic Bacteria. -- Anaerobic Bacteria -- Management of MMPs -- Conclusion -- References -- Chapter 10. Wound Healing Immunology and Bioffims / Christine A. Cochrane, Emma J. Woods, Paul Davis and John Barnett -- Introduction -- Overview of the Immune System -- The Innate Immune System and Wound Healing -- Identification of Microbial Intruders -- Components of the Innate Immune System -- Adaptive Immunity Wound Interactions -- Components of the Adaptive Immune System -- Coordinated Responses of the Innate and Adaptive Immune Systems -- Chronic Wounds -- Bacterial Immune Evasion -- Focus on S. aureus and P. aeruginosa Immune Evasion. -- Biofilm Formation -- Conclusion -- References -- Chapter 11. Antimicrobial Interventions for Wounds / Steven L. Percival, Steven L. Percival and Rose A. Cooper -- Introduction -- Types of Antimicrobial Agents -- The Rationale for Using Antimicrobial Interventions in Wounds -- Physical/Mechanical Methods for Reduction/Removal of Bioburden and Biofilms -- Debridement -- Enzymic Debridement -- Biological Debridement -- Antibiotics -- Antiseptics -- Iodine -- Mode of Action -- Effectiveness on Biofilms -- Silver -- Mode of Action -- Efficacy on Biofilms -- Polyhexamethylene Biguanides (PHMB) -- Mode of Action -- Efficacy against Biofilms -- Chlorhexidine -- Mode of Action -- Efficacy on Biofilms -- Acetic Acid. -- Mode of Action -- Efficacy on Biofilms -- Honey -- Mode of Action -- Efficacy on Biofilms -- Hydrogen Peroxide -- Mode of Action -- Efficacy on Biofilms -- Lactoferrin -- Mode of Action -- Efficacy on Biofilms -- Xylitol -- Mode of Action -- Efficacy on Biofilms -- Bacteriophages -- Mode of Action -- Effectiveness on Biofilms -- Ethylenediamine ibtraacetic Acid (EDTA) -- Mode of Action -- Effectiveness of Biofilms -- Quorum-Sensing Inhibitors -- Essential Oils -- Conclusions -- References -- Chapter 12. Wound Dressings and Other Topical Treatment Modalities in Bioburden Control / Benjamin A. Lipsky -- Introduction -- Wound Dressings -- Generic Dressing Classes -- Hydrocolloids -- Alginate Dressings -- Negative Pressure Wound Therapy -- Biosurgery -- Honey -- Hype/bade Oxygen -- Sequestration -- Control of Bacterial Virulence Determinants -- Dressing Leakage and Strike-Through -- The Microbiological Barrier Properties of Dressings -- The Value of Close Association of Dressing with the Wound Bed -- Fluid Handling Properties: Absorption/Retention, Lateral Wicking, Sequestration -- Conclusions -- References -- Chapter 13. Factors Affecting the Healing of Chronic Wounds: An Iconoclastic View / Richard White and Marissa J. Carter -- Introduction -- Pressure Ulcers as an Example of Chronic Wounds -- Colonization, Infections, and Wound Healing -- The Chronic Wound: What to Do? -- Basic Wound Care -- Compliance with Basic Wound Care -- Basic Wound Care Clinical Practice Guidelines -- The Technology Ceiling -- A Short History of High-Tech Wound Healing 'Treatments -- The Verdict on Advanced Wound-Healing 'Technologies -- Efficacy versus Effectiveness -- Ischemia and Cellular Hypoxia -- Where Do We Go from Here? -- Silver-Impregnated Wound Dressings as an Example of Advanced Technology -- The Concept -- Clinical Use of Silver-Impregnated Dressings -- Systematic Review and Meta-Analysis -- Conclusions -- References.
Subject(s):
ISBN:
  • 9781420079937 (hardcover : alk. paper)
  • 142007993X (hardcover : alk. paper)
LCCN:
2010005449
OCLC:
495598953
Related name:
RCP:
C - S