DNA repair in cancer therapy : molecular targets and clinical applications / edited by Mark R. Kelley.

Format
Book
Language
English
Εdition
1st ed.
Published/​Created
Amsterdam ; Boston : Academic Press, 2012.
Description
xiii, 316 pages : illustrations ; 29 cm

Availability

Copies in the Library

Location Call Number Status Location Service Notes
ReCAP - Remote StorageRC270.8 .D53 2012 Q Browse related items Request

    Details

    Subject(s)
    Bibliographic references
    Includes bibliographical references and index.
    Contents
    • Introduction and overview of current targets: bench to clinic / Mark R. Kelley
    • 2. MGMT a critical DNA repair gene target for chemotherapy resistance / Stanton L. Gerson and Lili Liu
    • 3. Blockade of base excision repair: inhibition of small lesions results in big consequences to cancer cells / Melissa Fishel and Carlo Vascotto
    • 4. PARP inhibitors - scientific rationale and clinical development for cancer / Ruth Plummer, Nicola J. Curtin and Yvette Drew
    • 5. inhibiting selective DNA polymerases for therapeutic intervention / Anthony J. Berdis
    • 6. Targeting the nucleotide excision repair pathway for therapeutic applications / John Turchi and Stephan M. Patrick
    • 7. Homologous recombination and ATM/ATR targets / Henning Willers, Lee Zou and Heike N. Pfaffle
    • 8. DNA double strand break repair by nonhomologous end joining and its clinical relevance / Michael Weinfeld and Susan Lees-Miller
    • 9. Defective MMR-c-Abl-p73-GADD45alpha expression in cancer chemoresistance / David Boothman and Long Shan Li
    • 10. DNA repair signaling targets / Susan Ashwell
    • 11. Redox regulation of DNA repair and therapeutic / Millie M. Georgiadis
    • 12. Personalized cancer medicine: DNA repair alterations is a promising predictive marker in cancer / Srinivasan Madhusudan
    • 13. The role of DNA damage and repair in neurotoxicity caused by cancer therapies / Michael R. Vasko
    • 14. Future directions with DNA repair inhibitors / Mark R. Kelley.
    ISBN
    • 9780123849991
    • 0123849993
    OCLC
    711573687
    RCP
    C - S
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    Supplementary Information