Cancer on trial : oncology as a new style of practice / Peter Keating and Alberto Cambrosio.

Author
Keating, Peter, 1953- [Browse]
Format
Book
Language
English
Published/​Created
Chicago : The University of Chicago Press, [2012], ©2012.
Description
xviii, 456 pages : illustrations ; 24 cm

Availability

Copies in the Library

Location Call Number Status Location Service Notes
ReCAP - Remote StorageRC254.5 .K43 2012 Browse related items Request

    Details

    Subject(s)
    Bibliographic references
    Includes bibliographical references and index.
    Contents
    • From "nonentity" to global network: the rise of a new style of biomedical practice
    • An early career in clinical oncology
    • About this book
    • A capsule history of cancer clinical trials
    • Cancer clinical trials as a new style of practice
    • The protocol
    • Before there were trials
    • Cancer hospitals and cancer institutes
    • Diagnosing cancer
    • Treating cancer
    • Prognosticating cancer
    • Testing therapies
    • The emergence of clinical cancer research (1955-66)
    • A landmark clinical trial
    • Curing leukemia: the vamp trial
    • A collective undertaking
    • The elements of innovation
    • What about the patients?
    • The collective turn: cooperative groups as epistemic organizations
    • Assembling the US cooperative system
    • Screening for drugs: from mice to humans
    • Tinkering with the cooperative group structure
    • Meanwhile in Europe
    • Clinical trial statistics
    • What is a random sample?
    • What is statistical significance?
    • Statisticians, statistics, and early cooperative clinical trials
    • Statisticians at the NIH
    • Statisticians in Paris
    • Fabricating the tools of the trade
    • Controversial methods
    • The emergence of the phase system
    • Criticism and the redefinition of clinical cancer trials as an autonomous form of research
    • Clinical cancer research under fire
    • The reorganization of screening and clinical trials in the United States
    • Surgery and radiotherapy in the cooperative groups
    • An avalanche of numbers from the new style of practice (1965-89)
    • A web of trials
    • Breast cancer and its trials
    • The lessons of the breast cancer trials
    • The emergence of combination chemotherapy
    • The multiple meanings of breast cancer trials
    • Statisticians, data centers, and the organization of large-scale clinical trials
    • Centers of calculation: us statisticians and the data center
    • The mechanics of data production
    • Meanwhile in Europe, take two
    • Back in the USA: group statisticians and NCI statisticians
    • Insiders' dissent: the randomization debate
    • A relational space of substances and regimens
    • The clinical evaluation of substances
    • Screening substances: the animal screen
    • Procuring compounds
    • Oncopolitics? reshaping collaborative research
    • Centralization or coordination? the European debate
    • Clinical trials as clinical research: the US debate
    • Oncology in the community
    • Targeted therapy, targeted trials (1990-2006)
    • Second interlude: molecular biology and oncogenes
    • The rise of molecular biology
    • Cancer and molecular biology: 1960-80
    • The clinical isolation of human oncogenes
    • Oncogenes and oncoproteins since 1982
    • Magic bullets? the Gleevec trials
    • Molecular biology and targeted substances
    • The trials of a targeted therapy
    • Where did Gleevec come from?
    • Monitoring data, managing risks
    • A medical oncologist and his patients
    • Patients and activists
    • Targeted therapy and clinical cancer research
    • Introduction: molecular biology and translational research
    • Molecular biology and the US cooperative groups
    • The reorganization of the drug discovery process and the transformation of the NCI screen
    • Clinical trials in a targeted age
    • More oncopolitics
    • Looking back and looking forward
    • The observational alternative to clinical cancer trials
    • Comparative effectiveness and clinical trials.
    ISBN
    • 9780226428918 (cloth : alk. paper)
    • 0226428915 (cloth : alk. paper)
    LCCN
    2011019445
    OCLC
    713181629
    RCP
    C - S
    Statement on language in description
    Princeton University Library aims to describe library materials in a manner that is respectful to the individuals and communities who create, use, and are represented in the collections we manage. Read more...