Princeton University Library Catalog

Neurobiology of Huntington's disease : applications to drug discovery / edited by Donald C. Lo, Robert E. Hughes.

Boca Raton : CRC Press/Taylor & Francis Group, c2010.
xx, 312 p. : ill. ; 25 cm.
Summary note:
"In 1993, the genetic mutation responsible for Huntington's disease (HD) was identified. Considered a milestone in human genomics, this discovery has led to nearly two decades of remarkable progress that has greatly increased our knowledge of HD, and documented an unexpectedly large and diverse range of biochemical and genetic perturbations that seem to result directly from the expression of the mutant huntingtin gene" "Neurobiology of Huntington's Disease: Applications to Drug Discovery presents a thorough review of the issues surrounding drug discovery and development for the treatment of this paradigmatic neurodegenerative disease. Drawing on the expertise of key researchers in the field, the book discusses the basic neurobiology of Huntington's disease and how its monogenic nature confers enormous practical advantages for translational research, including the creation of robust experimental tools, models, and assays to facilitate discovery and validation of molecular targets and drug candidates for HD." "While the development of effective drug treatments for Huntington's disease continues to be tremendously challenging, a highly interactive and cooperative community of researchers and clinical investigators now brings us to the threshold of potential breakthroughs in the quest for therapeutic agents. The impressive array of drug discovery resources outlined in the text holds much promise for treating this devastating disease, providing hope to long-suffering Huntington's disease patients and their families."--BOOK JACKET.
Bibliographic references:
Includes bibliographical references and index.
Chapter 1. Huntington's Disease: Clinical Features and Routes to Therapy / Roger L. Albin -- Chapter 2. Huntington's Disease Pathogenesis: Mechanisms and Pathways / Victor V. Pineda -- Chapter 3. Protein Interactions and Target Discovery in Huntington's Disease / Robert E. Hughes -- Chapter 4. Target Validation for Huntington's Disease / David S. Howland -- Chapter 5. High-Throughput and High-Content Screening for Huntington's Disease Therapeutics / Brent R. Stockwell -- Chapter 6. Value of Invertebrate Genetics and Biology to Develop Neuroprotective and Preventive Medicine in Huntington's Disease / Christian Neri -- Chapter 7. Mouse Models for Validating Preclinical Candidates for Huntington's Disease / Michelle Gray -- Chapter 8. Pharmaceutical Development for Huntington's Disease / Robert Pacifici -- Chapter 9. RNA- and DNA-Based Therapies for Huntington's Disease / Neil Aronin -- Chapter 10. Recombinant Intrabodies as Molecular Tools and Potential Therapeutics for Huntington's Disease / Paul H. Patterson -- Chapter 11. Biomarkers to Enable the Development of Neuroprotective Therapies for Huntington's Disease / H. Diana Rosas -- Chapter 12. Huntington's Disease: Clinical Experimental Therapeutics / Ira Shoulson.
  • 9780849390005 (hardcover : alk. paper)
  • 0849390001 (hardcover : alk. paper)
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