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Protein misfolding diseases : current and emerging principles and therapies / edited by Marina Ramirez-Alvarado, Jeffery W. Kelly, Christopher M. Dobson.
Format
Book
Language
English
Published/Created
Hoboken, N.J. : Wiley, [2010], ©2010.
Description
xxx, 1045 pages, 24 unnumbered pages of plates : illustrations (some color)illustrations (some color, ) ; 25 cm.
Availability
Copies in the Library
Location
Call Number
Status
Location Service
Notes
ReCAP - Remote Storage
RC632.P7 P763 2010
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Details
Subject(s)
Proteins
—
Metabolism
—
Disorders
[Browse]
Protein folding
[Browse]
Amyloidosis
[Browse]
Related name
Ramirez-Alvarado, Marina
[Browse]
Kelly, Jeffery W.
[Browse]
Dobson, C. M. (Christopher M.)
[Browse]
Series
Wiley series in protein and peptide science.
[More in this series]
Wiley series on protein and peptide science
Summary note
"Protein misfolding/aggregation diseases are a medical puzzle that has baffled researchers for many years. These diseases are characterized by the presence of protein deposits, or amyloid fibrils, which gather in the intracellular and/or extracellular spaces in a variety of tissues. Unchecked, the process of amyloidogenesis leads to proteotoxicity, cell loss, and eventually organ dysfunction, and causes such well-known and devastating diseases as Alzheimer's, Parkinson's, and Mad Cow." "Employing a diversity of research approaches, including chemical and biophysical, cellular, and animal models, the authors investigate various amyloid diseases and outline progress made in understanding them in this important book. Included are novel strategies to combat a wide variety of degenerative diseases." "Protein Misfolding Diseases uses the latest medical data from expert scientists and protein misfolding clinicians to launch a multi-targeted assault on the process of amyloid fibril formation. Fresh insight into the etiology of these maladies helps researchers gain a thorough understanding of the bases of these diseases and offers guidance in designing therapeutic strategies to build on promising new findings---and bring hope one step closer to reality."--BOOK JACKET.
Bibliographic references
Includes bibliographical references and index.
Contents
Foreword / R. John Ellis
Introduction to the Wiley Series on Protein and Peptide Science / Vladimir N. Uversky
PART I. PRINCIPLES OF PROTEIN MISFOLDING
1. Why Proteins Misfold / Fabrizio Chiti
2. Endoplasmic Reticulum Stress and Oxidative Stress: Mechanisms and Link to Disease / Randal J. Kaufman
3. Role of Molecular Chaperones in Protein Folding / F. Ulrich Hartl
4. Kinetic Models for Protein Misfolding and Association / Frank A. Ferrone
5. Toxicity in Amyloid Diseases / Massimo Stefani
6. Autophagy: An Alternative Degradation Mechanism for Misfolded Proteins / Ana Maria Cuervo
7. Role of Posttranslational Modifications in Amyloid Formation / Sylvia Tracz
8. Unraveling Molecular Mechanisms and Structures of Self-Perpetuating Prions / Susan Lindquist
9. Caenorhabditis elegans as a Model System to Study the Biology of Protein Aggregation and Toxicity / Richard I. Morimoto
10. Using Drosophila to Reveal Insight Into Protein Misfolding Diseases / Nancy M. Bonini
11. Animal Models to Study the Biology of Amyloid-β Protein Misfolding in Alzheimer Disease / Karen H. Ashe
PART II. PROTEIN MISFOLDING DISEASE: GAIN-OF-FUNCTION AND LOSS-OF-FUNCTION DISEASES
12. Alzheimer Disease: Protein Misfolding, Model Systems, and Experimental Therapeutics / Philip C. Wong
13. Prion Disease Therapy: Trials and Tribulations / Byron Caughey
14. Misfolding and Aggregation in Huntington Disease and Other Expanded Polyglutamine Repeat Diseases / Ronald Wetzel
15. Systemic Amyloidoses / Joel N. Buxbaum
16. Hemodialysis-Related Amyloidosis / Sheena E. Radford
17. Copper-Zinc Superoxide Dismutase, Its Copper Chaperone, and Familial Amyotrophic Lateral Sclerosis / P. John Hart
18. Alpha-1-Antitrypsin Deficiency / David H. Perlmutter
19. Folding Biology of Cystic Fibrosis: A Consortium-Based Approach to Disease / Philip Thomas
20. Thiopurine S-Methyltransferase Pharmacogenomics: Protein Misfolding, Aggregation, and Degradation / Richard M. Weinshilboum
21. Gaucher Disease / Tim Edmunds
22. Cataract as a Protein-Aggregation Disease / Jonathan A. King
23. Islet Amyloid Polypeptide / Daniel P. Raleigh
PART III. ROLE OF ACCESSORY MOLECULES AND RISK FACTORS
24. Role of Metals in Alzheimer Disease / Ashley I. Bush
25. Why Study the Role of Heparan Sulfate in In Vivo Amyloidogenesis? / John Ancsin
26. Serum Amyloid P Component / Steve Wood
27. Role of Oxidatively Stressed Lipids in Amyloid Formation and Toxicity / Hiroaki Komatsu
28. Role of Oxidative Stress in Protein Misfolding and/or Amyloid Formation / Paul Wentworth, Jr.
29. Aging and Aggregation-Mediated Proteotoxicity / Andrew Dillin
PART IV. MEDICAL ASPECTS OF DISEASE: DIAGNOSIS AND CURRENT THERAPIES
30. Imaging of Misfolded Proteins / Harry LeVine, III
31. Diagnosis of Systemic Amyloid Diseases / Morie A. Gertz
32. Identification of Biomarkers for Diagnosis of Amyloid Diseases: Quantitative Free Light-Chain Assays / Jerry A. Katzmann
33. Real-Time Observation of Amyloid-β Fibril Growth by Total Internal Reflection Fluorescence Microscopy / Yuji Goto
34. Current and Future Therapies for Alzheimer Disease / Todd E. Golde
35. Current Therapies for Light-Chain Amyloidosis / Shaji Kumar
36. Familial and Senile Amyloidosis Caused by Transthyretin / Merrill D. Benson
37. Identifying Targets in β-Synuclein Metabolism to Treat Parkinson Disease and Related Disorders / Michael G. Schlossmacher
38. Emerging Molecular Targets in the Therapy of Dialysis-Related Amyloidosis / Vittorio Bellotti
39. Familial Amyloidosis Caused by Lysozyme / Mireille Dumoulin
40. Therapeutic Prospects for Polyglutamine Disease / Kenneth H. Fischbeck
PART V. APPROACHES FOR NEW AND EMERGING THERAPIES
41. Chemistry and Biology of Amyloid Inhibition / Mark A. Findeis
42. Immunotherapy in Secondary and Light-Chain Amyloidosis / Jonathan Wall
43. Anti-Misfolding and Anti-Fibrillization Therapies for Protein Misfolding Disorders / Claudio Soto
44. Therapies Aimed at Controlling Gene Expression, Including Up-Regulating a Chaperone or Down-Regulating an Amyloidogenic Protein / Paul J. Muchowski
45. Understanding and Ameliorating the TTR Amyloidoses / Jeffery W. Kelly.
Show 49 more Contents items
ISBN
9780471799283 (cloth)
0471799289 (cloth)
LCCN
2009027972
OCLC
426115364
RCP
C - S
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