Molecular toxicology / P. David Josephy with Bengt Mannervik and Paul Ortiz de Montellano.

Author
Josephy, P. David [Browse]
Format
Book
Language
English
Published/​Created
Oxford ; New York : Oxford University Press, 1997.
Description
xiv, 368 p. : ill. ; 26 cm.

Details

Subject(s)
Molecular toxicology [Browse]
Summary note
  • Molecular Toxicology reflects the revolution that toxicology has undergone in the last decade, as the molecular and genetic basis of the science - including drug metabolism, carcinogenesis, programmed cell death, and DNA repair - has been elucidated. It is the first text to explain the principles of toxicology in depth and from the perspective of modern biochemistry and molecular biology, while also providing a sense of the historical development of the science.
  • Emphasizing the latest molecular biological approaches, the book covers xenobiotic biotransformation; reactive intermediates and their interactions with macromolecules; cloning expression, and analysis of the enzymes of biotransformation; and molecular toxicology of aromatic amines, nitrosamines, polycyclic aromatic hydrocarbons, and chlorinated compounds. The toxicology of oxygen and oxidative stress is also covered in depth.
  • . Extensively referenced, up-to-date, and rigorous, Molecular Toxicology is an ideal textbook for advanced undergraduate and graduate courses in molecular and biochemical toxicology, and also serves as a valuable resource for instructors and practicing scientists.
Bibliographic references
Includes bibliographica references and index.
Contents
1. Biochemical Background -- 2. Molecular Biology and Its Applications in Toxicology -- 3. Biological Oxidations -- 4. Superoxide and Superoxide Dismutase -- 5. Hydrogen Peroxide, Catalase, and Peroxidases -- 6. The Respiratory Burst -- 7. Lipid Peroxidation -- 8. Oxidative Stress in the Erythrocyte -- 9. Introduction to Xenobiotic Metabolism -- 10. Glucuronide Formation -- 11. Glutathione and Detoxication -- 12. Arylamine N-Acetyltransferase -- 13. Sulfotransferase -- 14. Cytochrome P-450 -- 15. The AH Receptor and the Toxicity of Chlorinated Aromatic Compounds -- 16. Identification of DNA Adducts -- 17. Chemical Mutagenesis -- 18. Carcinogenesis: The Genetic Targets -- 19. Polycyclic Aromatic Hydrocarbon Carcinogenesis -- 20. Aromatic Amines and Other N-Aryl Compounds.
ISBN
0195093402
LCCN
95024812
OCLC
558397934
RCP
C - S