Details

Subject(s)

• Clinical trials—Statistical methods [Browse]

Series

Wiley series in probability and statistics [More in this series]

Summary note

"This Second Edition of the critically hailed Clinical Trials builds on the text's reputation as a straightforward and authoritative presentation of statistical methods for clinical trials. Readers are introduced to the fundamentals of design for various types of clinical trials and then skillfully guided through the complete process of planning the experiment, assembling a study cohort, assessing data, and reporting results. Throughout the process, the author alerts readers to problems that may arise during the course of the trial and provides commonsense solutions." "The author bases the revisions and updates on his own classroom experience, as well as feedback from students, instructors, and medical and statistical professionals involved in clinical trials. The Second Edition greatly expands its coverage, ranging from statistical principles to controversial topics, including alternative medicine and ethics. At the same time, it offers more pragmatic advice for issues such as selecting outcomes, sample size, analysis, reporting, and handling allegations of misconduct."--BOOK JACKET.

Bibliographic references

Includes bibliographical references (p. 613-658 ) and indexes.

Contents

• 1. Preliminaries
• 2. Clinical trials as research
• 3. Why clinical trials are ethical
• 4. Contexts for clinical trials
• 5. Statistical perspectives
• 6. Clinical trials as experimental designs
• 7. Random error and bias
• 8. Objectives and outcomes
• 9. Translational clinical trials
• 10. Dose-finding designs
• 11. Sample size and power
• 12. The study cohort
• 13. Treatment allocation
• 14. Treatment effects monitoring
• 15. Counting subjects and events
• 16. Estimating clinical effects
• 17. Prognostic factor analyses
• 18. Reporting and authorship
• 19. Factorial designs
• 20. Crossover designs
• 21. Meta-analyses
• 22. Misconduct and fraud in clinical research
• A. Data and programs
• B. Notation and terminology
• C. Abbreviations
• D. Nuremberg Code
• E. Declaration of Helsinki
• F. NCI data and safety monitoring policy
• G. NIH data and safety monitoring policy
• H. Royal Statistical Society code of conduct.

Show 27 more Contents items

ISBN

0471727814 (cloth : alk. paper)

LCCN

2005040833

OCLC

57682616

International Article Number

• 9780471727811

RCP

C - S

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