Genetics of complex human diseases : a laboratory manual / edited by Ammar Al-Chalabi, Laura Almasy.

Format
Book
Language
English
Published/​Created
Cold Spring Harbor, N.Y. : Cold Spring Harbor Laboratory Press, c2009.
Description
ix, 220 p. : ill. (some col.) ; 29 cm.

Details

Subject(s)
Medical genetics [Browse]
Related name
Bibliographic references
Includes bibliographical references and index.
Contents
1. Introduction / Ammar Al-Chalabi and Laura Almasy -- 2. "Statistics 101" - A Primer for the Genetics of Complex Human Disease / Janet Sinsheimer -- 3. Linkage Analysis of Discrete Traits / Ingrid B. Borecki and John P. Rice -- 4. Epidemiologic Considerations in Complex Disease Genetics / John Gallacher -- 5. Variance Component Methods for Analysis of Complex Phenotypes / Laura Almasy and John Blangero -- 6. Multiple Testing and Power Calculations in Genetic Association Studies / Hon-Cheong So and Pak C. Sham -- 7. Introduction to Genetic Association Studies / Cathryn M. Lewis and Jo Knight -- 8. Genome-Wide Association Studies / Ammar Al-Chalabi -- 9. Introduction to Linkage Disequilibrium, the HapMap, and Imputation / Benjamin M. Neale -- 10. Meta-Analysis of Genome-Wide Association Studies / Paul I. W. de Bakker, Benjamin M. Neale and Mark J. Daly -- 11. Gene-Environment Interaction and Common Disease / Ruth J. F. Laos and Nicholas J. Wareham -- 12. Family-Based Genetic Association Tests / Eden R. Martin and Evadnie Rampersaud -- 13. Copy-Number Variation and Common Human Diseases / Dheeraj Malhotra and Jonathan Sebat -- 14. Oncogenomics / Simon J. Furney, Gunes Gundem and Nuria Lopez-Bigas -- 15. When the Genetic Code Is Not Enough-How Sequence Variations Can Affect Pre-mRNA Splicing and Cause (Complex) Disease / Brage Storstein Andresen and Adrian R. Krainer -- 16. Laboratory Methods for High-Throughput Genotyping / Howard J. Edenberg and Yunlong Liu -- 17. Gene Set Analysis and Network Analysis for Genome-Wide Association Studies / Inti Pedroso and Gerome Breen.
ISBN
  • 9780879698829 (hardcover : alk. paper)
  • 0879698829 (hardcover : alk. paper)
  • 9780879698836 (pbk. : alk. paper)
  • 0879698837 (pbk. : alk. paper)
LCCN
2009023930
OCLC
402542181
RCP
C - S

Supplementary Information