Adaptive design methods in clinical trails / Shein-Chung Chow, Mark Chang.

Author
Chow, Shein-Chung, 1955- [Browse]
Format
Book
Language
English
Published/​Created
Boca Raton : Chapman & Hall/CRC, c2007.
Description
277 p. : ill. ; 24 cm.

Details

Subject(s)
Related name
Series
  • Chapman & Hall/CRC biostatistics series ; 17. [More in this series]
  • Chapman & Hall/CRC biostatistics series ; 17
Summary note
"One of the first books on the topic, Adaptive Design Methods in Clinical Trials presents the principles and methodologies in adaptive design and analysis the pertain to adaptations made to trial or statistical procedures that are based on accrued data of ongoing clinical trials. The book also offers a well-balanced summary of current regulatory perspectives and recently developed statistical methods in this area."--BOOK JACKET.
Bibliographic references
Includes bibliographical references (p. [255]-267) and index.
Contents
1. Introduction -- 2. Protocol amendment -- 3. Adaptive randomization -- 4. Adaptive hypotheses -- 5. Adaptive dose-escalation trials -- 6. Adaptive group sequential design -- 7. Adaptive sample size adjustment -- 8. Adaptive seamless phase II/III designs -- 9. Adaptive treatment switching -- 10. Bayesian approach -- 11. Clinical trial simulation -- 12. Case studies.
ISBN
  • 1584887761
  • 9781584887768
LCCN
2006048510
OCLC
70408042
RCP
C - S