Princeton University Library Catalog

Cancer susceptibility : methods and protocols / edited by Michelle Webb.

Format:
Book
Language:
English
Published/​Created:
Totowa, N.J. : Humana ; London : Springer [distributor], 2010.
Description:
xi, 295 p. : ill. (some col.) ; 27 cm.
Series:
Bibliographic references:
Includes bibliographical references and index.
Contents:
he identification of colon cancer susceptibility genes by using genome-wide scans -- Prioritizing candidate genetic modifiers of BRCA1 and BRCA2 using a combinatorial analysis of global expression and polymorphism association studies of breast cancer -- Microarray-based comparative genomic hybridization (array-CGH) as a useful tool for identifying genes involved in Glioblastoma (GB) -- Multiplex Amplifiable Probe Hybridization (MAPH) methodology as an alternative to comparative genomic hybridization (CGH) -- Utilizing Saccharomyces cerevisiae to identify aneuploidy and cancer susceptibility genes -- Computational identification of cancer susceptibility loci -- Digital candidate gene approach (DigiCGA) for identification of cancer genes -- The use of denaturing high performance liquid chromatography (DHPLC) for mutation scanning of hereditary cancer genes -- Enhanced mismatch mutation analysis: simultaneous detection of point mutations and large scale rearrangements by capillary electrophoresis, application to BRCA1 and BRCA2 -- Economical protocol for combined single-strand conformation polymorphism and heteroduplex analysis on a standard capillary electrophoresis apparatus -- Mutational screening of hMLH1 and hMSH2 that confer inherited colorectal cancer susceptibility using denature gradient gel electrophoresis (DGGE) -- s-RT-MELT: a novel technology for mutation screening -- Zoom-in array comparative genomic hybridization (aCGH) to detect germline rearrangements in cancer susceptibility genes -- Development of a scoring system to screen for BRCA1/2 mutations -- Use of splicing reporter minigene assay to evaluate the effect on splicing of unclassified genetic variants -- Functional analysis of human BRCA2 variants using a mouse embryonic stem cell-based assay -- Developing functional assays for BRCA1 unclassified variants.
Subject(s):
ISBN:
  • 9781607617587 (hbk.)
  • 1607617587 (hbk.)
OCLC:
615896345
Related name:
RCP:
C - S