Chemical library design / edited by Joe Zhongxiang Zhou.

Format
Book
Language
English
Published/​Created
New York, N.Y. : Humana Press, [2011], ©2011.
Description
x, 362 pages : illustrations (some color) ; 27 cm.

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    Details

    Subject(s)
    Series
    Bibliographic references
    Includes bibliographical references and index.
    Contents
    • Historical overview of chemical library design
    • Chemoinformatics and library design
    • Molecular library design using multi-objective optimization methods
    • A scalable approach to combinatorial library design
    • Application of free-Wilson selectivity analysis for combinatorial library design
    • Application of QSAR and shape pharmacophore modeling approaches for targeted chemical library design
    • Combinatorial library design from reagent pharmacophore fingerprints
    • Docking methods for structure-based library design
    • Structure-based library design in efficient discovery of novel inhibitors
    • Structure-based and property-compliant library design of 11[beta]-HSD1 adamantyl amide inhibitors
    • Design of screening collections for successful fragment-based lead discovery
    • Fragment-based drug design
    • LEAP into the Pfizer Global Virtual Library (PGVL) space: Creation of readily synthesizable design ideas automatically
    • The design, annotation, and application of a kinase-targeted library
    • PGVL hub: An integrated desktop tool for medicinal chemists to streamline design and synthesis of chemical libraries and singleton compounds
    • Design of targeted libraries against the human Chk1 kinase using PGVLhub
    • GLARE: A tool for product-oriented design of combinatorial libraries
    • CLEVER: A general design tool for combinatorial libraries.
    OCLC
    680278836
    RCP
    C - S
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