Princeton University Library Catalog

Origin of cancers : clinical perspectives and implications of a stem-cell theory of cancer / Shi-Ming Tu.

Author:
Tu, Shi-Ming [Browse]
Format:
Book
Language:
English
Published/​Created:
New York ; London : Springer, c2010.
Description:
xviii, 239 p. : ill. (some col.) ; 25 cm.
Series:
  • Cancer treatment and research (Unnumbered) [More in this series]
  • Cancer treatment and research, 0927-3042
Bibliographic references:
Includes bibliographical references and index.
Contents:
1. Introduction -- 2. Cancer Myths -- Introduction -- Stem-Cell Origin of Cancers -- Dedifferentiation of Cancer -- Magic Bullets -- Multistep Carcinogenesis -- Cancer Signatures -- Epithelial-to-Mesenchymal Transition -- Gene Therapy -- Cancer Vaccine -- "Hypothesis-Generating" Research -- "Translational" Research -- Technologic vs. Scientific Breakthroughs -- Curing Cancer -- Conclusion -- References -- 3. History of Cancer -- Introduction -- Paleo-oncology -- Civilization vs. Age -- Written Evidence -- Brief History of Cancer -- History of the Stem-Cell Theory -- Saint Peregrine -- War on Cancer -- Conclusion -- References -- 4. Origin of Cancer -- Introduction -- Cancer Statistics -- Origin of Cancer -- Theoretical Oncologists -- Oncogenes -- The "Two-Hit" Hypothesis -- Initiation and Promotion -- Multistep Carcinogenesis -- Origins of Cancer, Revisited -- Stem-Cell Origin of Cancers -- Defining Idea -- Conclusion -- References -- 5. Stem Cells -- Introduction -- Meristem Cells -- Regeneration -- The Cell Concept -- Finding Stem Cells -- The Nature of Stem Cells -- Stemness -- The Question of Stemness -- The Stemness Within -- Parthenogenesis -- Beyond Stemness -- Cloning -- Reprogramming -- Unknown Unknowns -- Portrait of a Stem Cell -- Conclusion -- References -- 6. Stem Cells and Cancer -- Introduction -- A Tale of Two Cells -- Plight of the Tasmanian Devil -- Secondary Malignancy -- Stem-Cell Therapy -- Chronic Injury and Repair -- Cancer and Aging -- Met: The Missing Link? -- Telomerase in Cancer and Stem Cells -- Aneuploidy -- Conclusion -- References -- 7. Cancer Stem Cells -- Introduction -- Matter and Energy -- Invention of the Telephone -- Pioneers of Cancer Stem Cell Research -- Cancer Stem Cells -- Origin of Cancer Stem Cells -- The Making of a Rogue Cell -- Snags in the Stem-Cell Theory -- Spontaneous Remissions -- Succisa Virescit -- Putative Progenitor Stem Cells -- The CML Model -- Stem Cell vs. Progenitor Cell -- Stem-Cell Theory of Cancer -- Conclusion -- References -- 8. Cancer Niche -- Introduction -- The Dynamic Niche -- The Embryonic Niche -- Yin and Yang -- Niche Matters -- Donor-Cell Leukemia -- Stromal Factors -- Epithelial-Stromal Interactions -- Hypoxia -- Niche as an Investigative Medium -- Niche as a Therapeutic Medium -- Conclusion -- References -- 9. Ontogeny and Oncology -- Introduction -- The Nature of the Beast -- The Power of Reiteration -- Reactivation of Embryonic Genes -- Resurgence vs. Reprogramming -- Asymmetric Division -- Polycomb Silencers -- Epithelial-to-Mesenchymal Transition -- Compartmentalization of Cancer -- Clinical Implications -- Conclusion -- References -- 10. Diagnosis and Prognosis -- Introduction -- Cancer 101 -- Personalized Cancer -- Lethal vs. Indolent Cancers -- Stem-Cell Hierarchy -- Selection vs. Evolution -- Disease Selection by Therapy -- Diagnosis and Prognosis -- Methods and Norms -- Rosetta Stone or Tower of Babel? -- A Modest Proposal -- Conclusion -- References -- 11. Cancer Targets -- Introduction -- Target du Jour -- Paradigm Shift -- Stem-Cell Theory -- Death by a Thousand "Hits" -- The Problem with the Gene Theory -- Necessity or Redundancy? -- Credentialing Cancer Targets -- The Making of Human Cancer Cells -- Field Defect -- Cancer Targets in Nonmalignant Cells -- Benign Prostatic Hypertrophy and Prostate Cancer -- Endometriosis and Ovarian Cancer -- Et Tu, Stromatogenesis? -- Targeted Therapy -- Clinical Implications -- Conclusion -- References -- 12. Heterogeneity of Cancer -- Introduction -- Apples and Oranges -- The Good, the Bad, and the Ugly -- Stem-Cell Theory -- Origin of Heterogeneity -- HOX Genes -- Stem Cells and Heterogeneity -- Pluripotency -- Genetic Instability -- Clinical and Biologic Implications -- Conclusion -- References -- 13. Metastasis -- Introduction -- Cell Migration and Tissue Repair -- A Perfect Storm -- The Metastatic Journey -- A Modern "Seed-and-Soil" Theory -- Stem Cells and Metastasis -- Final Fury -- Heterogeneity of Metastasis -- Host-Cell Interactions -- Stem-Cell Niche vs. Onco-Niche -- Clinical and Biologic Implications -- Conclusion -- References -- 14. Cancer Immunity -- Introduction -- Immune Surveillance -- Immunotolerance -- Human Leukocyte Antigen Expression -- HLA-G and Immunotolerance -- The Meaning of β2M -- Immune Activation -- Minimal Residual Disease -- Cancer Vaccines -- Melanoma -- Renal-Cell Carcinoma -- Cervical Carcinoma -- Prostate Carcinoma -- Autoimmunity -- Conclusion -- References -- 15. Drug Resistance -- Introduction -- The Return of Cancer -- Worst Enemies -- ABC Transporters -- DNA Repair -- Apoptosis -- "Teratomatous" Tumors -- The Enigma of Somatic Cells -- The Goldie-Coldman Principle -- The Gompertzian Model -- Clinical Pitfalls -- Clinical Gems -- An Exercise in Futility -- An Uphill Battle -- Conclusion -- References -- 16. Paradigm Shifts -- Introduction -- Dedifferentiation -- Genetic Mutations -- Multistep Carcinogenesis -- The Story of Adenoma -- It's the Stem Cell! -- Metastasis -- Cancer Niche -- Conclusion -- References -- 17. Experimental Proof -- Introduction -- The Culture of Cancer Research -- Fundamental Flaws -- Experimental Proof Already Extant? -- Mesenchymal Origin -- Transplantation Studies -- Heterogeneity Studies -- Metastasis Studies -- Experimental Proof Still to Be Found! -- Circulating Tumor Cells -- Hox Genes -- The Study of Stem Cells Helps the Study of Cancer -- The Study of Cancer Helps the Study of Stem Cells -- The Ultimate Experiment -- A Modest Proposal -- Conclusion -- References -- 18. Clinical Implications -- Introduction -- Response vs. Survival -- Clinical Trials -- The Problem with Randomization -- Clinical Perspectives -- Cancer Screening -- Cancer Targets -- Diagnosis and Prognosis -- Therapeutic Implications -- Chemoprevention -- Surgery -- Vaccine Therapy -- Stem-Cell Therapy -- Future Research Directions -- Cancer Stem Cells -- Stem-Cell Research -- Cancer Epigenetics -- Angiogenesis -- Conclusion -- References -- 19. Curing Cancer -- Introduction -- Conquest vs. Cure -- Personalized Therapy -- Chemoprevention -- Differentiation Therapy -- Surgery: To Operate or Not to Operate? -- Maintenance Therapy -- Targeted Therapy -- Basic Rules of Science -- Conclusion -- References -- 20. Epilogue -- Introduction -- Cancer's Boogeyman -- Legend of the Fall -- The Curse of Job -- The Big Fix -- A Tale of Two Cells -- Old Dogma and New Doctrine -- Trade-offs -- Quo Vadimus? -- Final Thoughts.
Subject(s):
ISBN:
  • 9781441959676 (hbk.)
  • 144195967X (hbk.)
  • 1441959688 (ebk.)
  • 9781441959683 (e-ISBN)
OCLC:
495781720
RCP:
C - S