Details

Subject(s)

• Antisense nucleic acids—Therapeutic use [Browse]

Related name

• Stein, Cy A. [Browse]
• Krieg, Arthur M. [Browse]

Bibliographic references

Includes bibliographical references and index.

Contents

• I. Chemistry, Old and New. 1. Oligonucleoside Methylphosphonates: Synthesis and Properties / Paul S. Miller. 2. Oligo(Nucleoside Phosphorothioate)s / Piotr Guga, Maria Koziolkiewicz and Andrzej Okruszek [et al.]. 3. Modified Oligodeoxynucleotides as Antisense Therapeutics / Peter H. Seeberger and Marvin H. Caruthers. 4. Novel Chemistry / Karl-Heinz Altmann, Bernard Cuenoud and Peter Von Matt
• II. Oligonucleotide Internalization, Mechanism of Action, and Non-Sequence Specificity. 5. Cellular Uptake and Biodistribution of Oligodeoxynucleotides / Basil Hanss, C. A. Stein and Paul E. Klotman. 6. Use of Cationic Lipid Complexes for Antisense Oligonucleotide Delivery / C. Frank Bennett. 7. Nonantisense Effects of Antisense Oligonucleotides / Leonard M. Neckers and Kanak Iyer. 8. Ribonuclease H-Mediated Antisense Effects of Oligonucleotides and Controls for Antisense Experiments / David M. Tidd
• III.A. Sequence-Specific Inhibition of Gene Expression.
• 9. The Development of C-5 Propyne Oligonucleotides as Inhibitors of Gene Function / W. Michael Flanagan and Richard W. Wagner. 10. The use of Antisense Oligonucleotides to Inhibit Expression of Isozymes of Protein Kinase C / Nicholas M. Dean, K. Lemonidis and R. McKay [et al.]. 11. BCR-ABL as a Target for Antisense Intervention / Stephen G. O'Brien and Toon F. C. M. Smetsers. 12. The NF-kB Transcription Factor / Ramaswamy Narayanan. 13. Disruption of the Map Kinase Signaling Pathway using Antisense Oligonucleotide Inhibitors Targeted to RAS and RAF Kinase / Brett P. Monia. 14. Protein Kinase A-Directed Antisense Blockade of Cancer Growth: Single Gene-Based Therapeutic Approach / Yoon S. Cho-Chung. 15. Use of Antisense Oligonucleotides in the Central Nervous System: Why Such Success? / Margaret M. McCarthy
• III.B. Applied Antisense Oligonucleotide Therapeutics.
• 16. Perturbing Hematopoietic Cell Gene Expression with Oligodeoxynucleotides: Research and Clinical Applications / Alan M. Gewirtz and Mariusz Z. Ratajczak. 17. BCL2 / Burkhard Jansen and Bob D. Brown. 18. Biological Activity of Guanosine Quartet-Forming Oligonucleotides / Robert F. Rando and Michael E. Hogan
• IV. Oligonucleotides as Anti-HIV Agents. 19. Perspectives on Antisense Technology against HIV / Jay E. Gee, Amelie Benoit de Coignac and Ian Robbins [et al.]. 20. In Vivo Pharmacokinetics of Oligonucleotides / Sudhir Agrawal. 21. Early Clinical Trials with GEM 91, A Systemic Oligodeoxynucleotide / R. Russell Martin
• V. Therapeutic Oligonucleotide Data Base: Pharmacokinetics, Immune Stimulation, and use as Antirestenotic Agents. 22. Antisense Therapy to Inhibit Angioplasty Restenosis / Leroy E. Rabbani and Weizheng Wang. 23. Pharmacokinetics of Oligonucleotides: A Review of Current Knowledge and Issues for the Future / Thomas L. Wallace and Paul A. Cossum.
• 24. Leukocyte Stimulation by Oligodeoxynucleotides / Arthur M. Krieg
• VI. Selected Oligodeoxynucleotide Developmental Topics: Splicing and Triplexes. 25. Modification of Alternative Splicing of Pre-mRNA by Antisense Oligonucleotides / Ryszard Kole. 26. Gene-Targeted Triple-Helix-Forming Oligonucleotides / Fedor Svinarchuk and Claude Malvy. 27. Triplex-Forming Oligonucleotides for Genetic Manipulation: An Alternative View / A. Fawad Faruqi and Peter M. Glazer
• VII. A Review of Ribozyme Technology. 28. Therapeutic Ribozymes: Principles, Applications, and Problems / John J. Rossi.

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ISBN

0471172790 (alk. paper)

LCCN

97017640

OCLC

37011242

RCP

C - S

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