An enantiospecific synthesis of jiadifenolide.

Author
Mighion, Jeffrey Diamond [Browse]
Format
Book
Language
English
Description
155 p. ; 29 cm.

Details

Summary note
Our strategy towards the synthesis of the neurotrophic natural product jiadifenolide is discussed. Jiadifenolide is a structurally complex seco-prezizaane natural product and our goals were to simplify the total synthesis of this compound using late stage C-H functionalization. It is our belief that the explorations into these late stage C-H functionalizations have taught us about the necessity for new technologies in this area while also demonstrating an effective strategy for the synthesis of these compounds. During the course of this synthesis many lessons were learned and some of the highlights included the use of the under utilized van Leusen reaction, the first use of Sanford's methyl acetoxylation in a synthesis, and the use of Danishefsky's iodoso Pummerer-like rearrangement.
Notes
Source: Dissertation Abstracts International, Volume: 76-04(E), Section: B.
Dissertation note
Ph.D. Princeton University 2014
In
Dissertation Abstracts International 76-04B(E).
ISBN
9781321376791
OCLC
908377436
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