Patterning in vertebrate development / edited by Cheryll Tickle.

Oxford ; New York : Oxford University Press, 2003.
xvii, 242 pages : illustrations (some color) ; 26 cm.


Summary note
  • One of the most fascinating problems in biology is how a single cell, the fertilized egg, gives rise to a new individual. The fertilized egg divides many times to form an embryo, and this new volume in the Frontiers in Molecular Biology series discusses the methods by which cells in distinct regions of an embryo become different, a process known as patterning. Patterning is fundamental to establishing the spatial organization of the developing embryo. It ensures that all the parts of the body are generated and that they form in exactly the right places. The ultimate in patterning is the formation of precise arrangements of specialized cells and tissues within each organ. Understanding the process of patterning during the embryonic development of vertebrates is an ongoing challenge for developmental biologists because vertebrates have an intricate and complex anatomy and histology. This new book is a comprehensive account of our current understanding of patterning in vertebrate development. The general.
  • Principles of vertebrate patterning and early embryology are explained first, then subsequent chapters address patterning in both the nervous system and specific parts of the body. Throughout the book, examples are drawn from a number of species and emphasis has been placed on recent discoveries about the molecular basis of patterning in vertebrates. Each chapter, written by experts in the field, is a detailed review of current research that yields new insights. Written by an outstanding list of contributors, Patterning in Vertebrate Development is a unique, timely, and authoritative review of this important field. As such it will be a valuable resource not only for researchers but also for advanced students and those who teach them. Book jacket.
Bibliographic references
Includes bibliographical references and index.
  • Patterning and positional information / L. Wolpert, M. Kerzberg
  • Positional information
  • Interpretation of positional information
  • Prepattern mechanisms
  • Insect development
  • Evolution and pattern
  • Laying down the vertebrate body plan / M. Davey
  • Xenopus early development illustrates the general principles
  • Chick, mouse, and zebrafish development
  • Early stages in chick, mouse, and zebrafish development
  • Relationship between the polarity of egg and embryo in chicks, mice, and zebrafish
  • Gastrulation in chick, mouse, and zebrafish
  • Patterning the Xenopus embryo / J.C. Smith, R. White
  • From oocyte to egg: establishing the animal-vegetal axis
  • Localized RNAs
  • Fertilization: establishing the dorsoventral axis
  • Cortical rotation
  • The [beta]-catenin pathway
  • Mesoderm induction: realizing the animal-vegetal axis
  • Cleavage divisions in Xenopus
  • Mesoderm induction
  • Mesoderm-inducing factors
  • Concentration-dependent effects of inducing factors
  • The functions of mesoderm-specific genes: Brachyury targets
  • Dorsalization: realizing the dorsoventral axis
  • Goosecoid, siamois, and twin
  • Xnr3
  • Inhibitors of BMP and Wnt signalling
  • Somite and axial development in vertebrates / Clementine Hofmann
  • Morphogenesis: development of the skeleton
  • Establishing the primary body axis: from primitive streak to somites
  • Constructing the vertebral column: differentiation of somites into dermomyotome and sclerotome
  • Differentiation and maturation: from sclerotomes to vertebrae, from cartilage to bone.
  • 0199638705 ((hbk.))
  • 9780199638703 ((hbk.))
  • 0199638691 ((pbk.))
  • 9780199638697 ((pbk.))
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