Details

Subject(s)

• Protein binding [Browse]
• Molecular recognition [Browse]
• Carrier proteins [Browse]
• Structure-activity relationships (Biochemistry) [Browse]

Related name

• Kleanthous, Colin [Browse]

Series

• Frontiers in molecular biology ; 31. [More in this series]
• Frontiers in molecular biology ; 31 [More in this series]

Summary note

"In the light of new information from the genome sequencing projects and the increase in structural information, this book brings together concepts and systems pertaining to protein-protein interactions in an examination of how and why proteins form complexes with each other. The emphasis of the text is on heteromeric complexes and uses well-studied model systems to explain the processes of forming complexes. There is an introductory section on the kinetics, thermodynamics, analysis, and classification of protein-protein interactions. Electron transfer proteins and integrin complexes represent weak affinity complexes. Anti-lysosomal antibodies, the MHC proteins and their interactions with T-cell receptors, and the protein interactions of eukaryotic signal transduction are the systems used to explain complexes with intermediate affinities. Throughout the book the common themes are the technologies which have had the greatest impact, how specificity is determined, how complexes are stabilized, and medical and industrial applications."--Jacket.

Bibliographic references

Includes bibliographical references and index.

Contents

• Kinetics and thermodynamics of protein-protein interactions / Joël Janin
• Analysis and classification of protein-protein interactions from a structural perspective / Susan Jones, Janet M. Thornton
• Protein-protein complexes formed by electron transfer proteins / F. Scott Mathews, A. Grant Mauk, Geoffrey r. Moore
• Molecular basis of integrin-dependent cell adhesion / Martin J. Humphries, Robert C. Liddington
• Structure and energetics of anti-lysozyme antibodies / Bradford C. Braden, Roberto J. Poljak
• Proteins of the major histocompatibility complex and their interactions with T-cell receptors / Tim R. Dafforn, Arthur M. Lesk
• Protein-protein interactions in eukaryotic signal transduction / Marko Hyvönen, Jake Begun, Tom Blundell
• Interaction of standard mechanism, canonical protein inhibitors with serine proteinases / Michael Laskowski, Jr., M.A. Qasim, Stephen M. Lu
• Nuclease inhibitors / Colin Kleanthous, Ansgar J. Pommer.

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ISBN

• 019963761X ((hbk. ; : alk. paper))
• 9780199637614 ((hbk. ; : alk. paper))
• 0199637601 ((pbk.))
• 9780199637607 ((pbk.))

LCCN

00047888

OCLC

44694600

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