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Mechanisms of protein folding / edited by Roger H. Pain.
Format
Book
Language
English
Εdition
2nd ed.
Published/Created
Oxford ; New York : Oxford University Press, 2000.
Description
xxvi, 433 pages, [16] pages of color plates : illustrations ; 25 cm.
Availability
Copies in the Library
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Call Number
Status
Location Service
Notes
Lewis Library - Stacks
QP551 .M369 2000
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Details
Subject(s)
Protein folding
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Related name
Pain, Roger H.
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Series
Frontiers in molecular biology ; 32.
[More in this series]
Frontiers in molecular biology ; 32
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Summary note
"The process by which newly synthesized polypeptide chains become their final 3-dimensional protein forms is clearly explained, providing students and researchers of various backgrounds with both a conceptual and technical understanding of the subject. The new Second Edition incorporates the significant improvements in the field such as advances in interpreting observed kinetic data, the development of technology to observe fast folding reactions, the molten globule state, and the vital role of chaperone proteins in protein folding. The emphasis on experimental approaches has been maintained but this edition does so within the explicit context of simulations and energy surfaces.
New discoveries of the central importance of protein folding and unfolding reactions in biology and medicine (including mutation and 'misfolding') are carefully explored. Three case studies elucidate the difficulties of studying protein folding in vivo."--Jacket.
Bibliographic references
Includes bibliographical references and index.
Contents
The nature and significance of protein folding / Christopher M. Dobson
Kinetic models in protein folding / Oliver Bieri and Thomas Kiefhaber
Early stages of protein folding / Heinrich Roder, Gülnur A. Elöve, and M.C. Ramachandra Shastry
Protein folding monitored by mass spectrometry / Carol V. Robinson
Folding events in the submillisecond range / Martin Gruebele
The molten globule state : the physical picture and biological significance / Kunihiro Kuwajima and Muneihito Arai
Transition states in protein folding / Valerie Daggett and Alan R. Fersht
Proline isomerization and its catalysis in protein folding / Jochen Balbach and Franz X. Schmid
Protein folding coupled to disulphide-bond formation / Thomas E. Creighton
Assembly of multi-subunit structures / Robert Seckler
Case study 1 : The folding process of apomyoglobin / Peter E. Wright and Robert L. Baldwin
Case study 2 : Folding of the collagen triple-helix and its naturally occurring mutants / Jean Baum and Barbara Brodsky
Case study 3 : Folding of influenza haemagglutinin in the living cell / Lars Ellgaard and Ari Helenius
Cellular functions of molecular chaperones / Michel R. Leroux and F. Ulrich Hartl
Protein folding and human disease / Stephen W. Raso and Jonathan King.
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ISBN
0199637881 ((pbk. ; : alk. paper))
9780199637881 ((pbk. ; : alk. paper))
019963789X ((hbk.))
9780199637898 ((hbk.))
LCCN
00058882
OCLC
44627036
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