Voltage-gated Ca2+ Channels: Pharmacology, Modulation and their Role in Human Disease [electronic resource] / edited by Jörg Striessnig.

Author
Striessnig, Jörg [Browse]
Format
Book
Language
English
Εdition
1st ed. 2023.
Published/​Created
Cham : Springer International Publishing : Imprint: Springer, 2023.
Description
1 online resource (319 pages)

Details

Subject(s)
Series
Summary note
The aim of this volume is to summarize novel findings on the function, pathophysiology, and regulation of voltage-gated Ca2+ channels and on novel concepts of their pharmacological modulation. Impressive insights into the role of channel function and regulation have come from Ca2+ channelopathies affecting the pore-forming as well as accessory subunits and channel-interacting proteins. Moreover, the long-sought molecular basis for key regulatory pathways have been discovered as well as exciting concepts of their subtype-selective pharmacological modulation.
Contents
  • Preface
  • Part 1 Modulation
  • Cav1.1Calcium Channel Signaling Complexes in Excitation–Contraction Coupling: Insights from Channelopathies
  • Mechanisms of Vascular CaV1.2 Channel Regulation During Diabetic Hyperglycemia
  • Sympathetic Nervous System Regulation of Cardiac Calcium Channels
  • Modulation of CaV1.2 Channel Function by Interacting Proteins and Post-Translational Modifications: Implications in Cardiovascular Diseases and COVID-19
  • Part 2 Pharmacological Approaches
  • Pathophysiological Roles of Auxiliary Calcium Channel α2δ Subunits
  • Design and Applications of Genetically-Encoded Voltage-Dependent Calcium Channel Inhibitors
  • Part 3 Disease insight from channelopathies: consequences for pharmacology and therapeutic strategies
  • CACNA1C-Related Channelopathies
  • CACNA1D-Related Channelopathies: From Hypertension to Autism
  • CACNA1A-Related Channelopathies: Clinical Manifestations and Treatment Options
  • CaV3.2 (CACNA1H) in Primary Aldosteronism,- CaV3.3 Channelopathies
  • Pathophysiological Roles of Auxiliary Calcium Channel α2δ Subunits.
ISBN
3-031-38437-7
Doi
  • 10.1007/978-3-031-38437-0
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