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Princeton University Library Catalog
Aspirin Dosing : A Patient-Centric Trial Assessing Benefits and Long-term Effectiveness (ADAPTABLE), United States, 2015-2020 / Adrian F. Hernandez.
Ann Arbor, Mich. : Inter-university Consortium for Political and Social Research [distributor], 2023.
1 online resource.
Hernandez, Adrian F.
Inter-university Consortium for Political and Social Research
ICPSR (Series) 38609
[More in this series]
The main objective of this pragmatic randomized clinical trial (PCT) is to identify the optimal dose of aspirin for secondary prevention in atherosclerotic cardiovascular disease (ASCVD). A total of 15,076 high-risk patients with a history of a myocardial infarction (MI) or documented ASCVD were randomized in a 1:1 ratio to receive 81 mgs versus 325 mgs of aspirin every day. This trial addressed the following specific aims: To compare the effectiveness of two doses of aspirin (81 mg and 325 mg) in reducing a composite of all-cause mortality and hospitalization for nonfatal MI, or nonfatal stroke, and the primary safety endpoint of major bleeding. Secondary endpoints include the components of the primary endpoint and hospitalization for transient ischemic attack, unstable angina, or coronary revascularization procedures. To compare the effects of aspirin in selected subgroups of patients by sex, age, race, Internet users vs. non-users, and those with diabetes or advanced chronic kidney disease (CKD). To develop and refine the infrastructure for PCORnet to conduct multiple comparative effectiveness trials in the future. To explore biological mediators of heterogeneity of response to aspirin and of impact on clinical events. Cf: http://doi.org/10.3886/ICPSR38609.v1
Type of data
Patients with atherosclerotic cardiovascular disease (ASCVD).
Also available as downloadable files.
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