LEADER 01726nam 2200373 i 4500001 99125422863306421 005 20210217150557.0 006 m o d | 007 cr -n--------- 008 210217s2011 gw a ob 001 0 eng d 020 3-642-18384-0 024 7 10.1007/978-3-642-18384-3 |2doi 035 (CKB)2670000000082789 035 (EBL)3066652 035 (SSID)ssj0000506105 035 (PQKBManifestationID)11320720 035 (PQKBTitleCode)TC0000506105 035 (PQKBWorkID)10514223 035 (PQKB)10534368 035 (DE-He213)978-3-642-18384-3 035 (MiAaPQ)EBC5585767 035 (MiAaPQ)EBC6351877 035 (Au-PeEL)EBL5585767 035 (OCoLC)728101769 035 (PPN)153866861 035 (EXLCZ)992670000000082789 040 MiAaPQ |beng |erda |epn |cMiAaPQ |dMiAaPQ 041 eng 050 4 TD174 |b.E344 2011 072 7 RNP |2bicssc 072 7 SCI026000 |2bisacsh 072 7 SCI013000 |2bisacsh 082 0 301.31 |223 245 00 Effect-directed analysis of complex environmental contamination / |cVolume editor, Werner Brack ; with contributions by Gerald T. Ankley [and thirty-five others]. 250 1st ed. 2011. 264 1 Heidelberg : |bSpringer, |c[2011] 264 4 |c©2011 300 1 online resource (356 p.) 336 text |btxt 337 computer |bc 338 online resource |bcr 490 1 The Handbook of Environmental Chemistry ; |vVolume 15 500 Description based upon print version of record. 546 English 505 0 Early Evolution of the Toxicity Identification Evaluation Process: Contributions from the United States Environmental Protection Agency Effluent Testing Program -- Recent Developments in Whole Sediment Toxicity Identification Evaluations: Innovations in Manipulations and Endpoints.-Considerations for Incorporating Bioavailability in EDA and Toxicity Identification Evaluation -- Diagnostic tools for EDA of mutagens, AhR agonists and endocrine disruptors -- Separation Techniques in EDA -- Simultaneous screening and chemical characterization of bioactive compounds using LC-MS based technologies -- Advanced GC-MS and LC-MS tools for structure elucidation in effect-directed analysis -- Computer Tools for Structure Elucidation in EDA -- EDA of mutagens in ambient airborne particles -- EDA of endocrine disruptors in aquatic ecosystems -- ED studies of pulp and paper mill effluents -- EDA of Ah-receptor mediated toxicants, mutagens and endocrine disruptors in sediments and biota -- Ecological relevance of key toxicants in aquatic systems. 520 Today more than 5 million chemicals are known and roughly 100,000 of them are frequently used, with both numbers rising. Many of these chemicals are ultimately released into the environment and may cause adverse effects to ecosystems and human health. Effect-directed analysis (EDA) is a promising tool for identifying predominant toxicants in complex, mostly environmental mixtures combining effect testing, fractionation and chemical analysis. In the present book leading experts in the field provide an overview of relevant approaches and tools used in EDA. This includes diagnostic biological tools, separation techniques and advanced analytical and computer tools for toxicant identification and structure elucidation. Examples of the successful application of EDA are discussed such as the identification of mutagens in airborne particles and sediments, of endocrine disruptors in aquatic ecosystems and of major toxicants in pulp and paper mill effluents. This book is a valuable, comprehensive and interdisciplinary source of information for environmental scientists and environmental agencies dealing with the analysis, monitoring and assessment of environmental contamination. 504 Includes bibliographical references and index. 588 Description based on print version record. 650 0 Pollution. 700 1 Brack, Werner |c(Environmental toxicologist), |eeditor. 700 1 Ankley, Gerald T. |q(Gerald Thomas), |d1959- |econtributor. 776 |z3-642-26789-0 776 |z3-642-18383-2 760 0 |tHandbook of Environmental Chemistry, Vol. 2 |w(CKB)991042732770172 830 0 Handbook of environmental chemistry ; |vVolume 15. 906 BOOK