Details

Subject(s)

• Immunological deficiency syndromes—Congresses [Browse]
• Adenosine deaminase—Congresses [Browse]
• Purines—Metabolism—Congresses [Browse]
• Enzymes—Congresses [Browse]

Related name

• Symposium on Enzyme Defects and Immune Dysfunction (1978 : London, England) [Browse]

Series

• Ciba Foundation symposium. New series ; 68. [More in this series]
• Ciba Foundation symposium. New series ; 68 [More in this series]

Notes

"Symposium on Enzyme Defects and Immune Dysfunction, held at the Ciba Foundation, London, 7th-9th November 1978"--Participants page.

Bibliographic references

Includes bibliographical references and indexes.

Language note

English

Contents

• Enzyme Defects and Immune Dysfunction; Contents; Chairman's introduction; Adenosine deaminase and purine nucleoside phosphorylase deficiency: how they were discovered and what they may mean; Discussion; Buridan's ass: one man's view of the immune system; Discussion; Clinical delineation of adenosine deaminase deficiency; Discussion; Immunological aberrations in purine nucleoside phosphorylase deficiencies; Discussion; Immunodeficiency due to transcobalamin II deficiency; Discussion; General Discussion I Model systems for study of enzyme deficiencies
• Nucleotide metabolism in cultured T cells and in cells of patients deficient in adenosine deaminase and purine nucleoside phosphorylase Discussion; Deoxyribonucleoside toxicity in adenosine deaminase and purine nucleoside phosphorylase deficiency: implications for the development of new immunosuppressive agents; Discussion; Ecto 5'-nucleotidase deficiency in primary hypogammaglobulinaemia; Discussion; General Discussion II The methylation hypothesis of adenosine toxicity; Enzymology of immunodeficiency states; Allosteric regulation of calf thymus ribonucleotide reductase; Discussion
• Adenosine deaminase: characteristics of the normal and mutant forms of the human enzyme Discussion; Purine nucleoside phosphorylase: the normal enzyme and structural alterations in immunodeficiency disease; Discussion; Purine nucleoside phosphorylase : immunodetection and characterization of the human enzyme; Enzyme replacement and other biochemical approaches to the therapy of adenosine deaminase deficiency; Discussion; An approach to the restoration of T cell function in a purine nucleoside phosphorylase deficient patient; Discussion; Purine metabolism in adenosine deaminase deficiency
• Final General Discussion Selective treatment of lymphoid malignancy with adenosine deaminase inhibitors Defects in differentiation underlying ADA and PNP deficiency; Search for new enzyme deficiencies; Index of contributors; Subject index

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ISBN

• 1-280-78379-6
• 9786613694188
• 0-470-72051-4
• 0-470-71819-6

OCLC

797918439

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