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020    1-280-18368-3
020    9786610183685
020    0-309-57045-X
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035    (OCoLC)70723111
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040    MiAaPQ |beng |erda |epn |cMiAaPQ |dMiAaPQ
041    eng
050  4 Q11 |b.N26 2002
082 0  500
110    Proceedings of the National Academy of Sciences |eCorporate Author
111 2  Sackler Colloquium on Self-Perpetuating Structural States in Biology, Disease, and Genetics |d(2002 : |cWashington, D.C.)
245 10 Self-perpetuating structural states in biology, disease, and genetics.
250    1st ed.
260    Washington, D.C. : |bNational Academy of Sciences, |cc2002.
300    1 online resource (140 p.)
336    text |btxt
337    computer |bc
338    online resource |bcr
546    English
505 0  Self-Perpetuating Structural States in Biology, Disease, and Genetics -- Copyright -- Contents -- Colloquium Self-perpetuating structural states in biology, disease, and genetics -- Colloquium Transmission of prions -- "NATURAL" TRANSMISSION OF PRIONS -- IATROGENIC TRANSMISSION OF PRIONS -- EXPERIMENTAL TRANSMISSION OF SURFACE-BOUND PRIONS -- CONCLUDING REMARKS -- Colloquium Conservation of a portion of the S.cerevisiae Ure2p prion domain that interacts with the full-length protein -- MATERIALS AND METHODS -- RESULTS -- DISCUSSION -- Colloquium Interactions among prions and prion "strains" in yeast -- MATERIALS AND METHODS -- RESULTS -- DISCUSSION -- Colloquium Identification of benzothiazoles as potential polyglutamine aggregation inhibitors of Huntington's disease by… -- MATERIALS AND METHODS -- RESULTS -- DISCUSSION -- Colloquium Chaperoning brain degeneration -- MATERIALS AND METHODS -- A DROSOPHILA MODEL FOR HUMAN NEURODEGENERATIVE DISEASE -- THE MOLECULAR CHAPERONE HSP70 IS A POTENT SUPPRESSOR OF POLYGLUTAMINE PATHOGENICITY -- CHAPERONE SUPPRESSION OF Α-SYNUCLEIN TOXICITY IN A DROSOPHILA MODEL FOR PARKINSON'S DISEASE -- ENDOGENOUS CHAPERONE ACTIVITY PLAYS A ROLE IN -SYNUCLEIN TOXICITY IN DROSOPHILA AND POTENTIALLY ALSO IN PARKINSON'S DISEASE -- DISCUSSION -- Colloquium Molecular chaperones as modulators of polyglutamine protein aggregation and toxicity -- MECHANISM OF POLYQ AGGREGATION -- RELATIONSHIP BETWEEN POLYQ AGGREGATION AND TOXICITY -- TRANSCRIPTIONAL DYSREGULATION BY POLYQ AGGREGATION -- ROLE OF MOLECULAR CHAPERONES IN POLYQ AGGREGATION AND TOXICITY -- ROLE OF THE UBIQUITIN-PROTEASOME SYSTEM IN POLYQ AGGREGATION AND TOXICITY -- PERSPECTIVES -- Colloquium Studies of the aggregation of mutant proteins in vitro provide insights into the genetics of amyloid diseases -- MATERIALS AND METHODS -- RESULTS -- DISCUSSION -- CONCLUSION.
505 8  Colloquium Sequence-dependent denaturation energetics: A major determinant in amyloid disease diversity -- METHODS -- RESULTS AND DISCUSSION -- Colloquium The insulation of genes from external enhancers and silencing chromatin -- AN INSULATOR AS AN ENHANCER-BLOCKING ELEMENT -- INSULATORS AS BARRIERS -- CONCLUSION -- Colloquium Histone H3 lysine 4 methylation is mediated by Set1 and promotes maintenance of active chromatin states in fission -- MATERIALS AND METHODS -- RESULTS -- DISCUSSION -- Colloquium Changes in the middle region of Sup35 profoundly alter the nature of epigenetic inheritance for the yeast prion… -- MATERIALS AND METHODS -- RESULTS -- DISCUSSION -- Colloquium Heritable chromatin structure: Mapping "memory" in histones H3 and H4 -- MATERIALS AND METHODS -- RESULTS -- DISCUSSION -- Colloquium Does heterochromatin protein 1 always follow code? -- HP1 FOLLOWS CODE -- ARE THERE MULTIPLE MECHANISMS FOR HP1 ASSOCIATION? -- HP1 INTERACTS WITH A MYRIAD OF PROTEINS -- HP1 REGULATES GENE EXPRESSION -- Colloquium Self-perpetuating epigenetic pili switches in bacteria -- CIS- AND TRANS-ACTING PAP SWITCH COMPONENTS -- PAP PHASE VARIATION MODEL -- SWITCH INPUTS -- OUTPUTS -- Colloquium Histone H3 variants specify modes of chromatin assembly -- H3 VARIANTS DETERMINE THE NUCLEOSOME ASSEMBLY PATHWAY -- CENTROMERES REPLICATE BEFORE THEIR SURROUNDING HETEROCHROMATIN -- HIGH-RESOLUTION MAPPING OF CENTROMERE REPLICONS -- INFERRING THE RI MACHINERY -- OPENING A SPACE FOR HISTONE REPLACEMENT -- THE RI TARGET SITES FOR H3 VARIANTS ARE IN DISTINCT NUCLEAR COMPARTMENTS -- WHY RI ASSEMBLY? -- CONCLUSIONS -- Colloquium Induction and maintenance of nonsymmetrical DNA methylation in Neurospora -- MAINTENANCE METHYLATION IN NEUROSPORA -- CLUES TO INVOLVEMENT OF METHYL/RIP-DNA BINDING PROTEINS AND HISTONE DEACETYLATION IN DNA METHYLATION.
505 8  THE DIM-5 HISTONE METHYLTRANSFERASE INTEGRATES HISTONE CODE INFORMATION AND CONTROLS DNA METHYLATION -- Colloquium Locus-specific control of asymmetric and CpNpG methylation by the DRM and CMT3 methyltransferase genes -- MATERIALS AND METHODS -- RESULTS -- DISCUSSION -- Colloquium RNA-directed DNA methylation in Arabidopsis -- EXPERIMENTAL PROCEDURES -- RESULTS -- DISCUSSION -- Self-Perpetuating Structural States in Biology, Disease, and Genetics.
500    "Arthur M. Sackler colloquia of the National Academy of Sciences."
500    Held in Washington, DC, on March 22-24, 2002.
500    Issued as: Proceedings of the National Academy of Sciences of the United States of America, v. 99, suppl. 4 (10 Dec. 2002).
504    Includes bibliographical references.
650  0 Biology |vCongresses.
650  0 Proteins |xConformation |vCongresses.
776     |z0-309-08445-8
711 2  Arthur M. Sackler Colloquia of the National Academy of Sciences |d(2002 : |cIrvine, Calif.)
730 0  Proceedings of the National Academy of the United States of America. |nV. 99, suppl. 4.
906    BOOK