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Self-perpetuating structural states in biology, disease, and genetics.
Corporate author
Proceedings of the National Academy of Sciences
[Browse]
Sackler Colloquium on Self-Perpetuating Structural States in Biology, Disease, and Genetics (2002 : Washington, D.C.)
[Browse]
Format
Book
Language
English
Εdition
1st ed.
Published/Created
Washington, D.C. : National Academy of Sciences, c2002.
Description
1 online resource (140 p.)
Availability
Available Online
Ebook Central Perpetual, DDA and Subscription Titles
Online Content
Details
Subject(s)
Biology
—
Congresses
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Proteins
—
Conformation
—
Congresses
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Related name
Arthur M. Sackler Colloquia of the National Academy of Sciences (2002 : Irvine, Calif.)
[Browse]
Notes
"Arthur M. Sackler colloquia of the National Academy of Sciences."
Held in Washington, DC, on March 22-24, 2002.
Issued as: Proceedings of the National Academy of Sciences of the United States of America, v. 99, suppl. 4 (10 Dec. 2002).
Bibliographic references
Includes bibliographical references.
Language note
English
Contents
Self-Perpetuating Structural States in Biology, Disease, and Genetics
Copyright
Contents
Colloquium Self-perpetuating structural states in biology, disease, and genetics
Colloquium Transmission of prions
"NATURAL" TRANSMISSION OF PRIONS
IATROGENIC TRANSMISSION OF PRIONS
EXPERIMENTAL TRANSMISSION OF SURFACE-BOUND PRIONS
CONCLUDING REMARKS
Colloquium Conservation of a portion of the S.cerevisiae Ure2p prion domain that interacts with the full-length protein
MATERIALS AND METHODS
RESULTS
DISCUSSION
Colloquium Interactions among prions and prion "strains" in yeast
Colloquium Identification of benzothiazoles as potential polyglutamine aggregation inhibitors of Huntington's disease by…
Colloquium Chaperoning brain degeneration
A DROSOPHILA MODEL FOR HUMAN NEURODEGENERATIVE DISEASE
THE MOLECULAR CHAPERONE HSP70 IS A POTENT SUPPRESSOR OF POLYGLUTAMINE PATHOGENICITY
CHAPERONE SUPPRESSION OF Α-SYNUCLEIN TOXICITY IN A DROSOPHILA MODEL FOR PARKINSON'S DISEASE
ENDOGENOUS CHAPERONE ACTIVITY PLAYS A ROLE IN -SYNUCLEIN TOXICITY IN DROSOPHILA AND POTENTIALLY ALSO IN PARKINSON'S DISEASE
Colloquium Molecular chaperones as modulators of polyglutamine protein aggregation and toxicity
MECHANISM OF POLYQ AGGREGATION
RELATIONSHIP BETWEEN POLYQ AGGREGATION AND TOXICITY
TRANSCRIPTIONAL DYSREGULATION BY POLYQ AGGREGATION
ROLE OF MOLECULAR CHAPERONES IN POLYQ AGGREGATION AND TOXICITY
ROLE OF THE UBIQUITIN-PROTEASOME SYSTEM IN POLYQ AGGREGATION AND TOXICITY
PERSPECTIVES
Colloquium Studies of the aggregation of mutant proteins in vitro provide insights into the genetics of amyloid diseases
CONCLUSION.
Colloquium Sequence-dependent denaturation energetics: A major determinant in amyloid disease diversity
METHODS
RESULTS AND DISCUSSION
Colloquium The insulation of genes from external enhancers and silencing chromatin
AN INSULATOR AS AN ENHANCER-BLOCKING ELEMENT
INSULATORS AS BARRIERS
CONCLUSION
Colloquium Histone H3 lysine 4 methylation is mediated by Set1 and promotes maintenance of active chromatin states in fission
Colloquium Changes in the middle region of Sup35 profoundly alter the nature of epigenetic inheritance for the yeast prion…
Colloquium Heritable chromatin structure: Mapping "memory" in histones H3 and H4
Colloquium Does heterochromatin protein 1 always follow code?
HP1 FOLLOWS CODE
ARE THERE MULTIPLE MECHANISMS FOR HP1 ASSOCIATION?
HP1 INTERACTS WITH A MYRIAD OF PROTEINS
HP1 REGULATES GENE EXPRESSION
Colloquium Self-perpetuating epigenetic pili switches in bacteria
CIS- AND TRANS-ACTING PAP SWITCH COMPONENTS
PAP PHASE VARIATION MODEL
SWITCH INPUTS
OUTPUTS
Colloquium Histone H3 variants specify modes of chromatin assembly
H3 VARIANTS DETERMINE THE NUCLEOSOME ASSEMBLY PATHWAY
CENTROMERES REPLICATE BEFORE THEIR SURROUNDING HETEROCHROMATIN
HIGH-RESOLUTION MAPPING OF CENTROMERE REPLICONS
INFERRING THE RI MACHINERY
OPENING A SPACE FOR HISTONE REPLACEMENT
THE RI TARGET SITES FOR H3 VARIANTS ARE IN DISTINCT NUCLEAR COMPARTMENTS
WHY RI ASSEMBLY?
CONCLUSIONS
Colloquium Induction and maintenance of nonsymmetrical DNA methylation in Neurospora
MAINTENANCE METHYLATION IN NEUROSPORA
CLUES TO INVOLVEMENT OF METHYL/RIP-DNA BINDING PROTEINS AND HISTONE DEACETYLATION IN DNA METHYLATION.
THE DIM-5 HISTONE METHYLTRANSFERASE INTEGRATES HISTONE CODE INFORMATION AND CONTROLS DNA METHYLATION
Colloquium Locus-specific control of asymmetric and CpNpG methylation by the DRM and CMT3 methyltransferase genes
Colloquium RNA-directed DNA methylation in Arabidopsis
EXPERIMENTAL PROCEDURES
Self-Perpetuating Structural States in Biology, Disease, and Genetics.
Show 63 more Contents items
Other title(s)
Proceedings of the National Academy of the United States of America. V. 99, suppl. 4.
ISBN
1-280-18368-3
9786610183685
0-309-57045-X
OCLC
70723111
923270925
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Self-perpetuating structural states in biology, disease, and genetics [electronic resource] / ed. by Susan Lindquist and Steven Henikoff.
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9977141933506421