Self-perpetuating structural states in biology, disease, and genetics.

Corporate author
Format
Book
Language
English
Εdition
1st ed.
Published/​Created
Washington, D.C. : National Academy of Sciences, c2002.
Description
1 online resource (140 p.)

Details

Subject(s)
Notes
  • "Arthur M. Sackler colloquia of the National Academy of Sciences."
  • Held in Washington, DC, on March 22-24, 2002.
  • Issued as: Proceedings of the National Academy of Sciences of the United States of America, v. 99, suppl. 4 (10 Dec. 2002).
Bibliographic references
Includes bibliographical references.
Language note
English
Contents
  • Self-Perpetuating Structural States in Biology, Disease, and Genetics
  • Copyright
  • Contents
  • Colloquium Self-perpetuating structural states in biology, disease, and genetics
  • Colloquium Transmission of prions
  • "NATURAL" TRANSMISSION OF PRIONS
  • IATROGENIC TRANSMISSION OF PRIONS
  • EXPERIMENTAL TRANSMISSION OF SURFACE-BOUND PRIONS
  • CONCLUDING REMARKS
  • Colloquium Conservation of a portion of the S.cerevisiae Ure2p prion domain that interacts with the full-length protein
  • MATERIALS AND METHODS
  • RESULTS
  • DISCUSSION
  • Colloquium Interactions among prions and prion "strains" in yeast
  • Colloquium Identification of benzothiazoles as potential polyglutamine aggregation inhibitors of Huntington's disease by…
  • Colloquium Chaperoning brain degeneration
  • A DROSOPHILA MODEL FOR HUMAN NEURODEGENERATIVE DISEASE
  • THE MOLECULAR CHAPERONE HSP70 IS A POTENT SUPPRESSOR OF POLYGLUTAMINE PATHOGENICITY
  • CHAPERONE SUPPRESSION OF Α-SYNUCLEIN TOXICITY IN A DROSOPHILA MODEL FOR PARKINSON'S DISEASE
  • ENDOGENOUS CHAPERONE ACTIVITY PLAYS A ROLE IN -SYNUCLEIN TOXICITY IN DROSOPHILA AND POTENTIALLY ALSO IN PARKINSON'S DISEASE
  • Colloquium Molecular chaperones as modulators of polyglutamine protein aggregation and toxicity
  • MECHANISM OF POLYQ AGGREGATION
  • RELATIONSHIP BETWEEN POLYQ AGGREGATION AND TOXICITY
  • TRANSCRIPTIONAL DYSREGULATION BY POLYQ AGGREGATION
  • ROLE OF MOLECULAR CHAPERONES IN POLYQ AGGREGATION AND TOXICITY
  • ROLE OF THE UBIQUITIN-PROTEASOME SYSTEM IN POLYQ AGGREGATION AND TOXICITY
  • PERSPECTIVES
  • Colloquium Studies of the aggregation of mutant proteins in vitro provide insights into the genetics of amyloid diseases
  • CONCLUSION.
  • Colloquium Sequence-dependent denaturation energetics: A major determinant in amyloid disease diversity
  • METHODS
  • RESULTS AND DISCUSSION
  • Colloquium The insulation of genes from external enhancers and silencing chromatin
  • AN INSULATOR AS AN ENHANCER-BLOCKING ELEMENT
  • INSULATORS AS BARRIERS
  • CONCLUSION
  • Colloquium Histone H3 lysine 4 methylation is mediated by Set1 and promotes maintenance of active chromatin states in fission
  • Colloquium Changes in the middle region of Sup35 profoundly alter the nature of epigenetic inheritance for the yeast prion…
  • Colloquium Heritable chromatin structure: Mapping "memory" in histones H3 and H4
  • Colloquium Does heterochromatin protein 1 always follow code?
  • HP1 FOLLOWS CODE
  • ARE THERE MULTIPLE MECHANISMS FOR HP1 ASSOCIATION?
  • HP1 INTERACTS WITH A MYRIAD OF PROTEINS
  • HP1 REGULATES GENE EXPRESSION
  • Colloquium Self-perpetuating epigenetic pili switches in bacteria
  • CIS- AND TRANS-ACTING PAP SWITCH COMPONENTS
  • PAP PHASE VARIATION MODEL
  • SWITCH INPUTS
  • OUTPUTS
  • Colloquium Histone H3 variants specify modes of chromatin assembly
  • H3 VARIANTS DETERMINE THE NUCLEOSOME ASSEMBLY PATHWAY
  • CENTROMERES REPLICATE BEFORE THEIR SURROUNDING HETEROCHROMATIN
  • HIGH-RESOLUTION MAPPING OF CENTROMERE REPLICONS
  • INFERRING THE RI MACHINERY
  • OPENING A SPACE FOR HISTONE REPLACEMENT
  • THE RI TARGET SITES FOR H3 VARIANTS ARE IN DISTINCT NUCLEAR COMPARTMENTS
  • WHY RI ASSEMBLY?
  • CONCLUSIONS
  • Colloquium Induction and maintenance of nonsymmetrical DNA methylation in Neurospora
  • MAINTENANCE METHYLATION IN NEUROSPORA
  • CLUES TO INVOLVEMENT OF METHYL/RIP-DNA BINDING PROTEINS AND HISTONE DEACETYLATION IN DNA METHYLATION.
  • THE DIM-5 HISTONE METHYLTRANSFERASE INTEGRATES HISTONE CODE INFORMATION AND CONTROLS DNA METHYLATION
  • Colloquium Locus-specific control of asymmetric and CpNpG methylation by the DRM and CMT3 methyltransferase genes
  • Colloquium RNA-directed DNA methylation in Arabidopsis
  • EXPERIMENTAL PROCEDURES
  • Self-Perpetuating Structural States in Biology, Disease, and Genetics.
Other title(s)
Proceedings of the National Academy of the United States of America. V. 99, suppl. 4.
ISBN
  • 1-280-18368-3
  • 9786610183685
  • 0-309-57045-X
OCLC
  • 70723111
  • 923270925
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