Details

Subject(s)

• Biosensors—Industrial applications [Browse]
• Biomolecules [Browse]
• Cytochemistry [Browse]
• Microfluidics [Browse]
• Molecular recognition [Browse]
• Nanofluids [Browse]

Editor

• Lagally, Eric [Browse]
• Iniewski, Krzysztof [Browse]

Series

Devices, Circuits, and Systems [More in this series]

Summary note

Preface Microtechnology and more recent nanotechnology methods have enabled the fabrication of a wide variety of new chemical and biological sensors. These sensors demonstrate exquisite sensitivity and low limits of detection, enabling exploration of new scientific frontiers. In particular, the novel physics that emerges at small length scales allows parallel, mass-fabricated sensors for detection to both single-cell and single-molecule limits. Stochastic differences between individual cells and molecules have been shown to play important roles in larger biological systems, and these novel sensors have begun to test and elucidate these effects. This book focuses on the combination of soft materials like elastomers and other polymers with materials like semiconductors, metals, and glass to form integrated detection systems for biological and chemical targets. Microfluidic advances in this arena include systems for forming and analyzing tiny droplets (so-called droplet microfluidics); the combination of electrostatic and dielectrics to manipulate droplets on the microscale; miniaturized separation systems, including electrophoresis, for detecting a wide range of genetic targets from single cells; and novel optical and mechanical detection methods at the single-cell and single-molecule scales. This book represents a snapshot of the state of the art from the world's leading microfluidics and nanotechnology laboratories. The combination of different materials at both of these length scales is driving a powerful new set of scientific inquiries that have to date been impossible to address using other technologies. The book is arranged in two major sections. In Part I, the authors discuss a number of unique detection technologies-- Provided by publisher.

Notes

Description based upon print version of record.

Bibliographic references

Includes bibliographical references.

Language note

English

Contents

• Front Cover; Contents; Preface; Editors; Contributors; Chapter 1: Toward Unsupervised Smart Chemical Sensor Arrays; Chapter 2: Active CMOS Biochip for Electrochemical DNA Assays; Chapter 3: Label-Free DNA Sensor Based on a Surface Long-Period Grating; Chapter 4: Measuring the Physical Properties of Cells; Chapter 5: Technologies for Low-Cost, Hall Effect-Based Magnetic Immunosensors; Chapter 6: Two-Dimensional Paper Networks for Automated Multistep Processes in Point-of-Care Diagnostics; Chapter 7: Droplet-Based Digital Microfluidics for Single-Cell Genetic Analysis
• Chapter 8: Droplet-Based Microfluidics for Biological Sample Preparation and AnalysisChapter 9: A Review of Tubeless Microfluidic Devices; Back Cover

Other title(s)

Biosensing to the single molecule limit

ISBN

• 9781351831482
• 1351831488
• 9781315215594
• 1315215594
• 9781138072398
• 1138072397
• 9781466594906
• 146659490X

OCLC

• 879945731
• 900547325

Doi

10.1201/b17020

Statement on responsible collection description

Princeton University Library aims to describe library materials in a manner that is respectful to the individuals and communities who create, use, and are represented in the collections we manage. Read more...