Rational basis for clinical translation in stroke therapy / edited by Giuseppe Micieli, Director of the Department of Emergency Neurology, IRCCS National Neurological Institute, C. Mondino Foundation, Pavia, Italy ; Diana Amantea, Department of

  • Boca Raton : CRC Press, [2015]
  • ©2015
1 online resource (528 p.)


Summary note
Stroke remains one of the major causes of death and long-term disability worldwide. Currently, the only approved therapy for the acute treatment of this disease is thrombolysis, a strategy that can only be applied to a small percentage of patients due to its narrow therapeutic window. Unfortunately, during the last years numerous promising drugs that showed neuroprotection in the experimental setting failed to translate into the clinic because of their toxicity or lack of efficacy.Researchers in the field now face the crucial need to develop effective stroke therapies and successfully translat
Description based upon print version of record.
Bibliographic references
Includes bibliographical references.
Source of description
Description based on online resource; title from PDF title page (ebrary, viewed August 08, 2014).
Language note
  • Front Cover; Contents; Series Preface; Preface; Contributors; Chapter 1: Stroke Units, Regional Systems of Emergency Stroke Care, and Telestroke Networks; Chapter 2: Overview of Endovascular Treatment and Revascularization Strategies in Acute Ischemic Stroke; Chapter 3: Benefits and Harms of Pharmacological Thrombolysis; Chapter 4: Mechanical Revascularization Strategies for Stroke Treatment; Chapter 5: Risk Factors and Restroke Prevention; Chapter 6: Genomics for the Advancement of Clinical Translation in Stroke; Chapter 7: Acute Stroke Imaging and Beyond
  • Chapter 8: Imaging the Penumbra : CTP or Perfusion-Diffusion MRI Mismatch?Chapter 9: Predictors of Hemorrhagic Transformation of Ischemic Stroke after Thrombolysis; Chapter 10: Imaging Approaches to Map the Penumbra in Preclinical Stroke Models; Chapter 11: Trial Design and Reporting Standards for Acute Intravascular Cerebral Thrombolysis; Chapter 12: Analysis and Interpretation of Outcome Measures in Stroke Clinical Trials; Chapter 13: Evaluation of Interventions in Stroke : The Cochrane Stroke Group Experience
  • Chapter 14: Neuroprotective Therapy : Failure and Future for Clinical ApplicationChapter 15: Stroke Model Guidelines and STAIR Recommendations for Preclinical Stroke Studies; Chapter 16: Animal Models of t-PA-Induced Hemorrhagic Transformation; Chapter 17: Assessment of Sensorimotor Symptoms in Rodents after Experimental Brain Ischemia; Chapter 18: Glutamate and Stroke : From NMDA to mGlu Receptors and Beyond; Chapter 19: Therapeutic Hypothermia for Acute Stroke; Chapter 20: Drug-Induced Hypothermia in Stroke : Current Status and New Therapeutic Approaches
  • Chapter 21: Immune Response in Cerebral Ischemia : Role of TLRsChapter 22: Polarization of Macrophages/Microglia toward an M2 Phenotype as a Therapeutic Strategy for Stroke Treatment; Chapter 23: Minocycline Repurposing for Acute Cerebral Hemorrhage; Chapter 24: NCX as a Key Player in the Neuroprotection Exerted by Ischemic Preconditioning and Postconditioning; Chapter 25: Cell-Based Therapies for Stroke; Chapter 26: The contribution of Neuroplasticity to Recovery after Stroke; Chapter 27: Stroke Rehabilitation Care : Management and Procedures
  • Chapter 28: Focal Treatment of Stroke-Related Spasticity in the Rehabilitation Setting : Clinical Exploitation of Botulinum ToxinChapter 29: Use of Antidepressants as Adjunctive Therapy to Improve Recovery after Ischemic Stroke; Back Cover
  • 0-429-16919-1
  • 1-4665-9497-7
  • 885121785
  • 889264307
  • 10.1201/b16285
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