Skip to search
Skip to main content
Catalog
Help
Feedback
Your Account
Library Account
Bookmarks
(
0
)
Search History
Search in
Keyword
Title (keyword)
Author (keyword)
Subject (keyword)
Title starts with
Subject (browse)
Author (browse)
Author (sorted by title)
Call number (browse)
search for
Search
Advanced Search
Bookmarks
(
0
)
Princeton University Library Catalog
Start over
Cite
Send
to
SMS
Email
EndNote
RefWorks
RIS
Printer
Bookmark
Ligand-Macromolecular Interactions in Drug Discovery [electronic resource] : Methods and Protocols / edited by Ana Cecília A. Roque.
Format
Book
Language
English
Εdition
1st ed. 2010.
Published/Created
Totowa, NJ : Humana Press : Imprint: Humana, 2010.
Description
1 online resource (X, 298 p.)
Availability
Available Online
Springer Nature - Complete Protocols
Online Content
Details
Subject(s)
Toxicology
[Browse]
Biochemistry
[Browse]
Editor
Roque, Ana Cecília A.
[Browse]
Roque, Ana Cecília A.
[Browse]
Roque, Ana Cecília A.
[Browse]
Series
Methods in Molecular Biology, 572
[More in this series]
Methods in Molecular Biology, 1064-3745 ; 572
[More in this series]
Summary note
Drug research has been greatly transformed by the "omics revolution" and advances in computational tools, combinatorial chemistry, and high throughput screening techniques (HTS). These implements have advanced the ability to identify target molecules that serve as points of attack for future medicines, the design and synthesis of potential lead compounds, and further characterization, screening, and assays for therapeutic efficacy and toxicity. In Ligand-Macromolecular Interactions in Drug Discovery: Methods and Protocols, experts in the field highlight the main principles and methodologies currently utilized in the study of molecular interactions between compounds, either natural or synthetic, and complementary biological targets, within the scope of drug discovery. Beginning with a historical perspective of drug research focusing on the contribution of genomics, proteomics, high-throughput methods, and computational developments in drug discovery, the book then delves into highly detailed methods on topics such as NMR spectroscopy, compound library design and synthesis, chemical and biological microarrays, and many others. Written in the highly successful Methods in Molecular Biology™ series format, chapters include introductions to their respective subjects, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Ligand-Macromolecular Interactions in Drug Discovery: Methods and Protocols will serve as an ideal guide to scientists in academia and in industry who are striving to further our knowledge of medicines.
Notes
Bibliographic Level Mode of Issuance: Monograph
Language note
English
Contents
Reviews
An Historical Overview of Drug Discovery
Ligand Macromolecule Interactions: Theoretical Principles of Molecular Recognition
X-Ray Crystallography in Drug Discovery
Virtual Screening of Compound Libraries
Protocols
Combinatorial Chemistry and the Synthesis of Compound Libraries
Ligand-Based Nuclear Magnetic Resonance Screening Techniques
Isothermal Titration Calorimetry and Differential Scanning Calorimetry
Adaptive Combinatorial Design of Focused Compound Libraries
Chemical Microarrays: A New Tool for Discovery Enzyme Inhibitors
Fluorescence Polarization and Time-Resolved Fluorescence Resonance Energy Transfer Techniques for PI3K Assays
Small Molecule Protein Interaction Profiling with Functional Protein Microarrays
Capillary Electrophoresis in Drug Discovery
SPR in Drug Discovery: Searching Bioactive Compounds in Plant Extracts
Application of Frontal Affinity Chromatography with Mass Spectrometry (FAC#x2013;MS) for Stereospecific Ligand#x2013;Macromolecule Interaction, Detection and Screening
GPC Spin Column HPLC#x2013;ESI-MS Methods for Screening Drugs Noncovalently Bound to Proteins
A Scintillation Proximity Assay for Fatty Acid Amide Hydrolase Compatible with Inhibitor Screening
A Natural Products Approach to Drug Discovery: Probing Modes of Action of Antitumor Agents by Genome-Scale cDNA Library Screening
Ligand#x2013;Macromolecule Interactions in Live Cells by Fluorescence Correlation Spectroscopy.
Show 17 more Contents items
Other title(s)
LIGAND-MACROMOLECULAR INTERACTIONS IN DRUG DISCOVERY
ISBN
9781607612445
Doi
10.1007/978-1-60761-244-5
Statement on language in description
Princeton University Library aims to describe library materials in a manner that is respectful to the individuals and communities who create, use, and are represented in the collections we manage.
Read more...
Other views
Staff view
Ask a Question
Suggest a Correction
Report Harmful Language
Supplementary Information
Other versions
Ligand-macromolecular interactions in drug discovery [electronic resource] : methods and protocols / edited by Ana Cećilia A. Roque.
id
9962809143506421
Ligand-macromolecular interactions in drug discovery : methods and protocols / edited by Ana Cećilia A. Roque.
id
9961967333506421