Potassium channels and their modulators : from synthesis to clinical experience / edited by J.M. Evans ... [et al.].

Format
Book
Language
English
Εdition
First edition.
Published/​Created
London ; Bristol, PA : Taylor & Francis, c1996.
Description
1 online resource (521 p.)

Details

Subject(s)
Related name
Series
  • Taylor & Francis series in pharmaceutical sciences. [More in this series]
  • The Taylor & Francis series in pharmaceutical sciences
Summary note
"Potassium ions K+ ions are vital in physiological processes, particularly with regard to the cardiovascular system. Modulators influence the channels through which these ions flow and the research into modulator drugs of these channels is the subject of rapidly-advancing research. This work is intended to be of use as a tool for those working in the pharmaceutical industry. Early chapters concentrate on the synthesis and structure-activity relationships of potassium channel modulators. These are followed by discussion on the application of these drugs to different target organs, such as the cardiovascular system and the airways. The book concludes with a broad overview of clinical experience and future prospects.; The authors show how potassium channel activators and potassium channel blockers each have a role to play as therapeutic agents for many disorders, including asthma and respiratory tract disorders, diseases of the central nervous system such as epilepsy, and vascular diseases such as angina, peripheral vascular disease and high blood pressure. This book should therefore also be of interest to those researching into this wide range of diseases."--Provided by publisher.
Notes
Description based upon print version of record.
Bibliographic references
Includes bibliographical references and index.
Language note
English
Contents
  • Book Cover; Title; Contents; Contributors; Foreword; Preface; The Synthesis and Chemistry of Benzopyran Related Potassium Channel Activators; Structure-Activity Relationships of Benzopyran Based Potassium Channel Activators; Syntheses and Structure-Activity Relationships of Pyridine Based Potassium Channel Activators; Conformational Analysis of Potassium Channel Activators; The Structure-Activity Relationships of Potassium Channel Blockers; Potassium Channels: Diversity, Assembly and Differential Expression
  • Potassium Channel Electrophysiology in Vascular Smooth Muscle Cells and the Site of Action of Potassium Channel OpenersEffects of Potassium Channel Activators in Isolated Blood Vessels; In Vivo Vascular Effects of Potassium Channel Activators; Cardiac Potassium Channel Modulators: Potential for Antiarrhythmic Therapy; Cardioprotective Properties of Potassium Channel Modulators; Potassium Channel Activators: Airway Pharmacology and Bronchial Asthma; Potassium Channels in Pancreatic -Cells: Modulation, Pharmacology and their Role in the Regulation of Insulin Secretion
  • Potassium Channels and their Modulation in Urogenital Tract Smooth MusclesPotassium Channel Modulators and the Central Nervous System; Potassium Channel Modulators: Clinical Experiences and Future Prospects; Abbreviations; Index of Compounds; Index
ISBN
  • 0-429-08125-1
  • 1-4822-7284-9
  • 1-280-09849-X
  • 9786610098491
  • 6610098492
  • 0-203-30441-1
OCLC
  • 475890703
  • 1027759385
Doi
  • 10.1201/9781482272840
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