Drug safety evaluation : methods and protocols / edited by Jean-Charles Gautier.

Format
Book
Language
English
Published/​Created
New York, NY : Humana Press, ©2011.
Description
xiii, 431 pages : illustrations (some color) ; 26 cm

Availability

Copies in the Library

Location Call Number Status Location Service Notes
Lewis Library - Lewis Library - Serials (Off-Site) QH506 .M45 1984 vol.691 Browse related items Request

    Details

    Subject(s)
    Editor
    Series
    Bibliographic references
    Includes bibliographical references and index.
    Contents
    • Part I. General toxicology. Developing combination drugs in preclinical studies / Alberto Lodola. Preclinical evaluation of juvenile toxicity / Paul C. Barrow, Stéphane Barbellion, and Jeanne Stadler
    • Part II. Pathology. Necropsy and sampling procedures in rodents / Laurence Fiette and Mohamed Slaoui. Histopathology procedures : from tissue sampling to histopathological evaluation / Mohamed Slaoui and Laurence Fiette. Principles and methods of immunohistochemistry / José A. Ramos-Vara. Tissue microarrays and digital image analysis / Denise Ryan, Laoighse Mulrane, Elton Rexhepaj, and William M. Gallagher
    • Part III. Genetic toxicology. Micronucleus assay and labeling of centromeres with FISH technique / Ilse Decordier, Raluca Mateuca, and Micheline Kirsch-Volders. The use of bacterial repair endonucleases in the comet assay / Andrew R. Collins
    • Part IV. Safety pharmacology. Manual whole-cell patch-clamping of the HERG cardiac K⁺ channel / Xiao-Liang Chen, Jiesheng Kang, and David Rampe
    • Part V. Investigative toxicology. Generation and analysis of transcriptomics data / Philip D. Glaves and Jonathan D. Tugwood. Protocols of two-dimensional difference gel electrophoresis to investigate mechanisms of toxicity / Emmanuelle Com, Albrecht Gruhler, Martine Courcol, and Jean-Charles Gautier. Protocols and applications of cellular metabolomics in safety studies using precision-cut tissue slices and carbon 13 NMR / Gabriel Baverel, Sophie Renault, Hassan Faiz, Maha El Hage, Catherine Gauthier, Agnès Duplany, Bernard Ferrier, and Guy Martin. Statistical analysis of quantitative RT-PCR results / Richard Khan-Malek and Ying Wang. Evaluation of mitochondrial respiration in cultured rat hepatocytes / Jean-Pierre Marchandeau and Gilles Labbe
    • Part VI. Screening assays for developmental toxicity. FETAX assay for evaluation of developmental toxicity / Isabelle Mouche, Laure Malesic, and Olivier Gillardeaux. Evaluation of embryotoxicity using the zebrafish model / Lisa Truong, Stacey L. Harper, and Robert L. Tanguay
    • Part VII. Chemical protein adducts. Protocols of in vitro protein covalent binding studies in liver / Jean-François Lévesque, Stephen H. Day, and Allen N. Jones. Utilization of MALDI-TOF to determine chemical-protein adduct formation in vitro / Ashley A. Fisher, Matthew T. Labenski, Terrence J. Monks, and Serrine S. Lau. Utilization of LC-MS/MS analyses to identify site-specific chemical protein adducts in vitro / Ashley A. Fisher, Matthew T. Labenski, Terrence J. Monks, and Serrine S. Lau. One-dimensional western blotting coupled to LC-MS/MS analysis to identify chemical-adducted proteins in rat urine / Matthew T. Labenski, Ashley A. Fisher, Terrence J. Monks, and Serrine S. Lau. Identification of chemical-adducted proteins in urine by multi-dimensional protein identification technology (LC/LC-MS/MS) / Matthew T. Labenski, Ashley A. Fisher, Terrence J. Monks, and Serrine S. Lau
    • Part VIII. Safety biomarkers. Optimization of SELDI for biomarker detection in plasma / Jean-Francois Léonard, Martine Courcol, and Jean-Charles Gautier. Differential proteomics incorporating iTRAQ labeling and multi-dimensional separations / Ben C. Collins, Thomas Y.K. Lau, Stephen R. Pennington, and William M. Gallagher. NMR and MS methods for metabonomics / Frank Dieterle, Björn Riefke, Götz Schlotterbeck, Alfred Ross, Hans Senn, and Alexander Amberg. Absolute quantification of toxicological biomarkers by multiple reaction monitoring / Thomas Y. K. Lau, Ben C. Collins, Peter Stone, Ning Tang, William M. Gallagher, and Stephen R. Pennington.
    Other format(s)
    Also available in an electronic version.
    ISBN
    • 9781603271868 ((alk. paper))
    • 1603271864 ((alk. paper))
    • 9781607618492 ((e-ISBN))
    • 1607618494 ((e-ISBN))
    LCCN
    2010937423
    OCLC
    678514802
    Statement on language in description
    Princeton University Library aims to describe library materials in a manner that is respectful to the individuals and communities who create, use, and are represented in the collections we manage. Read more...
    Other views
    Staff view